Severe cobalt intoxication following hip replacement revision: clinical features and outcome
Language English Country Great Britain, England Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chelating Agents therapeutic use MeSH
- Cobalt poisoning MeSH
- Middle Aged MeSH
- Humans MeSH
- Arthroplasty, Replacement, Hip adverse effects MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chelating Agents MeSH
- Cobalt MeSH
CONTEXT: Cobalt intoxication has become more frequent due to the wide use of metal hip implants. CASE DETAILS: A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved. CONCLUSION: We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit.
References provided by Crossref.org
