A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- akutní nemoc MeSH
- autonomní nervový systém účinky léků MeSH
- chemické bojové látky otrava MeSH
- chování zvířat účinky léků MeSH
- hyperkineze chemicky indukované prevence a kontrola MeSH
- krysa rodu Rattus MeSH
- molekulární struktura MeSH
- neuroprotektivní látky aplikace a dávkování chemie terapeutické užití MeSH
- neurotoxické syndromy etiologie prevence a kontrola MeSH
- obidoxim chlorid aplikace a dávkování chemie terapeutické užití MeSH
- organofosfáty MeSH
- otrava organofosfáty * MeSH
- oximy aplikace a dávkování chemie terapeutické užití MeSH
- potkani Wistar MeSH
- pyridinové sloučeniny aplikace a dávkování chemie terapeutické užití MeSH
- svalový tonus účinky léků MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- 1-(4-carbamoylpyridinium)-4-(3-fluoro-4-hydroxyiminomethylpyridinium)-but-2-ene MeSH Prohlížeč
- 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene MeSH Prohlížeč
- chemické bojové látky MeSH
- neuroprotektivní látky MeSH
- obidoxim chlorid MeSH
- organofosfáty MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- tabun MeSH Prohlížeč
The ability of the newly developed bispyridinium compound K203 and its fluorinated analogue KR-22836 to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the currently available reactivator of acetylcholinesterase-obidoxime. Tabun-induced neurotoxicity and the neuroprotective effects of all tested oximes in combination with atropine in rats poisoned with tabun at a sublethal dose (200 μg/kg intramuscularly (i.m.); 80% of LD(50) value) were monitored by a functional observational battery at 24 hr after tabun challenge. The results indicate that all tested oximes combined with atropine were able to survive tabun-poisoned rats 24 hr after tabun challenge while one non-treated tabun-poisoned rat died within 24 hr after tabun poisoning. All tested oximes combined with atropine were able to decrease tabun-induced neurotoxicity in the case of sublethal poisoning but they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. While the ability to reduce tabun-induced acute neurotoxicity of obidoxime and K203 was similar, the neuroprotective efficacy of KR-22836 was slightly higher compared to other tested oximes. Thus, the newly developed fluorinated analogue of K203, called KR-22836, is able to slightly increase the neuroprotective effectiveness of antidotal treatment of acute tabun poisonings compared to K203 and currently available obidoxime.
Citace poskytuje Crossref.org
Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
