Self-assembled polymeric chelate nanoparticles as potential theranostic agents
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chelating Agents chemistry MeSH
- Ions chemistry MeSH
- Copper chemistry MeSH
- Nanoparticles chemistry MeSH
- Drug Carriers chemistry MeSH
- Oxyquinoline analogs & derivatives chemistry MeSH
- Polyethylene Glycols chemistry MeSH
- Polymers chemistry MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 8-hydroxyquinoline-5-sulfonic acid MeSH Browser
- Chelating Agents MeSH
- Ions MeSH
- Copper MeSH
- Drug Carriers MeSH
- Oxyquinoline MeSH
- Polyethylene Glycols MeSH
- Polymers MeSH
Improvements in cancer diagnostics and therapy have recently attracted the interest of many different branches of science. This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers. Graft copolymers with a backbone containing 8-hydroxyquinoline-5-sulfonic acid chelating groups and poly(ethylene oxide) hydrophilic grafts are synthesized and characterized. The polymers assemble and form particles after the addition of a biometal cation, such as iron or copper. The obtained nanoparticles exhibit a hydrodynamic diameter of around 25 nm and a stability of at least several hours, which are counted as essential parameters for biomedical purposes. To prove their biodegradability, a model degradation with deferoxamine is performed and, together with high radiolabeling efficiency with copper-64, their possible use for nuclear medicine purposes is demonstrated.
Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic v v i Czech Republic
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