Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23291595
DOI
10.1016/j.steroids.2012.11.016
PII: S0039-128X(12)00330-3
Knihovny.cz E-resources
- MeSH
- Androstenes chemistry MeSH
- Hormone Antagonists chemical synthesis pharmacology MeSH
- Cytotoxins chemical synthesis pharmacology MeSH
- Estrone chemistry MeSH
- Catalysis MeSH
- Cholic Acid chemistry MeSH
- Humans MeSH
- Molecular Structure MeSH
- Cell Line, Tumor MeSH
- Pyridines chemistry MeSH
- Receptors, Steroid antagonists & inhibitors metabolism MeSH
- Steroids chemical synthesis pharmacology MeSH
- Cell Survival drug effects MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Androstenes MeSH
- Hormone Antagonists MeSH
- Cytotoxins MeSH
- Estrone MeSH
- etienic acid MeSH Browser
- Cholic Acid MeSH
- Pyridines MeSH
- Receptors, Steroid MeSH
- Steroids MeSH
There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using Cu(I) catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular "ribbons" are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.
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