Genetics of anti-EHV antibody responses in a horse population
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23582518
DOI
10.1016/j.rvsc.2013.03.011
PII: S0034-5288(13)00088-X
Knihovny.cz E-resources
- MeSH
- Phenotype MeSH
- Genotype MeSH
- Herpesvirus 1, Equid genetics immunology MeSH
- Herpesviridae Infections genetics immunology veterinary virology MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Horses MeSH
- Microsatellite Repeats MeSH
- Horse Diseases genetics immunology virology MeSH
- Statistics, Nonparametric MeSH
- Polymerase Chain Reaction veterinary MeSH
- Antibodies, Viral blood MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Viral MeSH
Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections.
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