Two cases of diabetic ketoacidosis in HNF1A-MODY linked to severe dehydration: is it time to change the diagnostic criteria for MODY?
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
PubMed
23610083
PubMed Central
PMC3747930
DOI
10.2337/dc13-0058
PII: dc13-0058
Knihovny.cz E-zdroje
- MeSH
- dehydratace komplikace MeSH
- diabetes mellitus 2. typu komplikace metabolismus MeSH
- diabetická ketoacidóza diagnóza etiologie metabolismus MeSH
- dospělí MeSH
- hepatocytární jaderný faktor 1-alfa metabolismus MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- hepatocytární jaderný faktor 1-alfa MeSH
OBJECTIVE: Hepatocyte nuclear factor-1A maturity-onset diabetes of the young (HNF1A-MODY) is a monogenic form of diabetes caused by heterozygous mutations in HNF1A. Currently, a history of diabetic ketoacidosis (DKA) is an exclusion criterion for genetic testing for MODY. HISTORY AND EXAMINATION: In this article, we describe two unrelated patients aged 17 and 24 years with severe DKA developed several years after the diagnosis of HNF1A-MODY. INVESTIGATION: Both patients were treated with insulin, but their metabolic control was poor (HbA1c 15%, 140 mmol/mol and 13%, 119 mmol/mol, respectively) due to noncompliance and missed insulin injections. In both patients, DKA followed a course of recurrent vomiting with dehydration and prerenal acute kidney injury. Their glycemia, blood pH, and base excess at admission were 97 mmol/L [1,748 mg/dL], 6.80, and -33 mmol/L (patient 1) and 34 mmol/L [613 mg/dL], 7.03, and -14 mmol/L (patient 2). CONCLUSIONS: This anecdotal observation supports the notion that a history of DKA does not exclude MODY.
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How can maturity-onset diabetes of the young be identified among more common diabetes subtypes?
Hidden MODY-Looking for a Needle in a Haystack