Fylogenetická analýza a genotypizace virů chřipky A/H3N2 izolovaných od pacientů hospitalizovaných s příznaky ILI (Influenza-Like Illnesses) v Nemocnici Na Bulovce v sezoně 2011/2012
[Phylogenetic analysis and genotyping of A/H3N2 Influenza viruses isolated from patients hospitalised with influenza-like illness symptoms in the na bulovce hospital in the season 2011/2012]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
23768089
PII: 40698
- MeSH
- Influenza, Human diagnosis virology MeSH
- Adult MeSH
- Phylogeny MeSH
- Genotype MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Influenza A Virus, H3N2 Subtype classification genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
Influenza A virus is an important cause of acute respiratory infections (ARI). Clinical manifestations of ARI vary from mild or moderate to life-threatening conditions requiring intensive care. Given the segmented genome, a large natural reservoir of other influenza virus subtypes, and antibody selection pressure in the population, the virus is variable and genetically unstable. The phylogenetic analysis and genotyping of A/H3N2 influenza viruses isolated from patients hospitalised with influenza-like illness symptoms in the Na Bulovce Hospital in the season 2011/2012 support the assumption that the pathogenicity is a polygenic trait modifiable by the host health status and seems not to be unambiguously associated with any specific mutations.
