Proteomic biomarkers for spontaneous preterm birth: a systematic review of the literature
Language English Country United States Media print-electronic
Document type Journal Article, Systematic Review
PubMed
24060632
DOI
10.1177/1933719113503415
PII: 1933719113503415
Knihovny.cz E-resources
- Keywords
- preterm delivery, proteomic, systematic review,
- MeSH
- Biomarkers blood metabolism MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Premature Birth diagnosis metabolism MeSH
- Proteomics methods MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Systematic Review MeSH
- Names of Substances
- Biomarkers MeSH
This review aimed to identify, synthesize, and analyze the findings of studies on proteomic biomarkers for spontaneous preterm birth (PTB). Three electronic databases (Medline, Embase, and Scopus) were searched for studies in any language reporting the use of proteomic biomarkers for PTB published between January 1994 and December 2012. Retrieved citations were screened, and relevant studies were selected for full-text reading, in triplicate. The search yielded 529 citations, 51 were selected for full-text reading and 8 studies were included in the review. A total of 64 dysregulated proteins were reported. Only 14-3-3 protein sigma, annexin A5, protein S100-A8, protein S100-A12, and inter-α-trypsin inhibitor heavy chain H4 were reported in more than 1 study, but results could not be combined due to heterogeneity in type of sample and analytical platform. In conclusion, according to the existing literature, there are no specific proteomic biomarkers capable of accurately predicting PTB.
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