Effect of collagen I gel on apoptosis of rat hepatic stellate cells
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Apoptosis drug effects MeSH
- Cell Culture Techniques MeSH
- Carbon Tetrachloride MeSH
- Cycloheximide MeSH
- Cytochalasin D MeSH
- Gliotoxin MeSH
- Liver Cirrhosis pathology MeSH
- Hepatic Stellate Cells drug effects pathology MeSH
- Collagen Type I pharmacology MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Rats, Sprague-Dawley MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Carbon Tetrachloride MeSH
- Cycloheximide MeSH
- Cytochalasin D MeSH
- Gliotoxin MeSH
- Collagen Type I MeSH
Activated hepatic stellate cells (HSC) are a major source offibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process.
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