The rare case of Alternaria alternata cutaneous and pulmonary infection in a heart transplant recipient treated by azole antifungals
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24112410
DOI
10.1111/dth.12096
Knihovny.cz E-resources
- Keywords
- Alternaria alternata, azole antifungals, heart transplantation,
- MeSH
- Alternaria drug effects immunology pathogenicity MeSH
- Alternariosis diagnosis drug therapy immunology microbiology MeSH
- Antifungal Agents administration & dosage MeSH
- Dermatomycoses diagnosis drug therapy immunology microbiology MeSH
- Immunocompromised Host MeSH
- Immunosuppressive Agents adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Opportunistic Infections diagnosis drug therapy immunology microbiology MeSH
- Lung Diseases, Fungal diagnosis drug therapy immunology microbiology MeSH
- Heart Transplantation adverse effects MeSH
- Triazoles administration & dosage MeSH
- Voriconazole administration & dosage MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Immunosuppressive Agents MeSH
- posaconazole MeSH Browser
- Triazoles MeSH
- Voriconazole MeSH
We report a case of Alternaria alternata cutaneous and pulmonary infection in a 62-year-old man after heart transplantation treated by azole antifungals. Alternaria spp. belong to a group of opportunistic dematiaceous fungi with worldwide distribution. The cutaneous form of the infection in human is very rare and occurs predominantly among immunosuppressed patients. Therefore, diagnosis is often delayed or not reached at all. Appropriate treatment is not standardized and remains a matter of discussion. According to current studies, the best results are obtained with systemic azole antifungal therapy combined with surgical intervention.
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