RHOA, SEMA3B, and CKAP2 expression in leukaemia of different types: the results of a pilot experiment
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
24280143
PII: file/5702/FB2013A0029.pdf
Knihovny.cz E-resources
- MeSH
- Cytoskeletal Proteins blood genetics MeSH
- Adult MeSH
- Leukemia blood genetics MeSH
- Humans MeSH
- Membrane Glycoproteins blood genetics MeSH
- Pilot Projects MeSH
- Protein Isoforms blood genetics MeSH
- Gene Expression Regulation, Leukemic * MeSH
- rhoA GTP-Binding Protein blood genetics MeSH
- Semaphorins blood genetics MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- CKAP2 protein, human MeSH Browser
- Cytoskeletal Proteins MeSH
- Membrane Glycoproteins MeSH
- Protein Isoforms MeSH
- rhoA GTP-Binding Protein MeSH
- RHOA protein, human MeSH Browser
- SEMA3B protein, human MeSH Browser
- Semaphorins MeSH
The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. In the blood of healthy donors, RHOA and CKAP2 gene expression was not detected, and low SEMA3B gene expression was observed. Significant elevation of expression of all the three genes was shown in the case of acute myelogenous leukaemia. In cases of remission of acute lymphoblastic leukaemia and myelodysplastic syndrome, no expression of all three genes was detected. The long isoform of the CKAP2 gene was highly expressed in most analysed types of leukaemia.
