Mycobacterium marinum, the cause of chronic systemic infections in fish, occasionally causes granulomatous skin and soft tissue lesions in humans. Cutaneous mycobacterial infection in two patients owing to unusual circumstances is presented in this report. The first patient was infected through improper hygienic behavior, while infection in the second patient was previously misdiagnosed as rheumatoid arthritis and treated with methylprednisolone for a period of three months, which resulted in a rare systemic spread of M. marinum into the bones of the hand, testis, and epididymis. Simultaneously, screening for possible sources of M. marinum infection in patients' aquaria revealed positive fish harboring VNTR profiles identical to those obtained for clinical isolates from patients.

Department of Clinical Microbiology and Parasitology County Hospital Pribram 261 95 Pribram Czech Republic

Department of Dermatovenerology General University Hospital and 1st Faculty of Medicine Charles University 128 21 Prague Czech Republic

Veterinary Research Institute Hudcova 70 621 00 Brno Czech Republic

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