Mechanizmy zmien dĺzky axónov a dendritov neurónu
[Mechanisms of growth of neuronal axons and dendrites]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Review
PubMed
24392595
- MeSH
- Actins metabolism MeSH
- Axons metabolism physiology MeSH
- Cell Growth Processes physiology MeSH
- Dendrites metabolism physiology MeSH
- Humans MeSH
- Microtubules metabolism MeSH
- Neurites metabolism physiology MeSH
- Neurons cytology metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Actins MeSH
Brain development is determined by neuronal differentiation including changes of cell polarity and asymetric growth of neuronal processes. Although, there are many unkown factors contributing to changes of lenght of neuronal cones, mounting experimental and review papers focus on changes of growth conus and role of axonal transport. In particular, mechanisms of actin/microtubule polymerisation and depolymerisation are important. Role of intracellular calcium is also significant. Normal and properly timed changes of lenght of axons and dendrites are dependent on interaction of neurons and glia. Moreover, regeneration of injured axons is dependent on growth factors secreted from glial cells. The aim of the present study is characterisation of the most important mechanisms underlying changes of lenght of neurites.