Evaluation of total adiponectin, adipocyte fatty acid binding protein and fibroblast growth factor 21 levels in individuals with metabolic syndrome
Language English Country Czech Republic Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24397811
DOI
10.33549/physiolres.932602
PII: 932602
Knihovny.cz E-resources
- MeSH
- Adiponectin blood MeSH
- Asymptomatic Diseases MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Dyslipidemias blood diagnosis MeSH
- Fibroblast Growth Factors blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Metabolic Syndrome blood diagnosis MeSH
- Fatty Acid-Binding Proteins blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adiponectin MeSH
- ADIPOQ protein, human MeSH Browser
- Biomarkers MeSH
- FABP4 protein, human MeSH Browser
- fibroblast growth factor 21 MeSH Browser
- Fibroblast Growth Factors MeSH
- Fatty Acid-Binding Proteins MeSH
Although many studies have investigated the relationships of several adipokines to metabolic syndrome (MetS), the interrelationships of adiponectin (ADP), adipocyte fatty acid binding protein (A-FABP) and fibroblast growth factor 21 (FGF 21) have not been described in detail. We examined 209 asymptomatic dyslipidemic patients divided into MetS+ (n=73) and MetS- (n=136) groups. The aim of study was to evaluate the relationships between observed adipokines, to compare the levels of total ADP, A-FABP and FGF 21 in individuals with and without MetS, and to elucidate the relationships of individual adipokines to lipid parameters, markers of insulin resistance and endothelial hemostatic markers in these groups. In MetS+ group, we found the independent positive association ADP with A-FABP (beta=0.4888, p=0.0382), A-FABP with FGF 21 (beta=0.3811, p=0.0002) and von Willebrand factor (beta=0.4502, p=0.0013), and FGF 21 with A-FABP (beta=0.4422, p=0.0002). Our study has confirmed the well-established risk profile of subjects with MetS, although clinically asymptomatic. MetS+ patients had also lower levels of ADP and higher levels of A-FABP and FGF 21. Our study evaluated the interrelationships of ADP, A-FABP and FGF 21 in asymptomatic dyslipidemic subjects with diagnosis of MetS. Especially strong association between A-FABP and FGF 21 needs to be clarified in further studies.
References provided by Crossref.org
Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes
