Silver-coated monolithic columns for separation in radiopharmaceutical applications
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
24478196
DOI
10.1002/jssc.201301325
Knihovny.cz E-zdroje
- Klíčová slova
- Capture, Iodide, Iodine, Monoliths, Silver nanoparticles,
- MeSH
- 3-jodobenzylguanidin izolace a purifikace MeSH
- kovové nanočástice chemie MeSH
- methylmetakryláty chemie MeSH
- poréznost MeSH
- povrchové vlastnosti MeSH
- radiofarmaka izolace a purifikace MeSH
- stříbro chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Názvy látek
- 3-jodobenzylguanidin MeSH
- GMA-EDMA MeSH Prohlížeč
- methylmetakryláty MeSH
- radiofarmaka MeSH
- stříbro MeSH
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In-house-prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m-iodobenzylguanidine labeled with radionuclide iodine-125.
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