Alkaloids from Boophone haemanthoides (Amaryllidaceae)
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24555277
Knihovny.cz E-resources
- MeSH
- Amaryllidaceae Alkaloids chemistry isolation & purification MeSH
- Phenanthridines isolation & purification MeSH
- Antineoplastic Agents, Phytogenic chemistry isolation & purification MeSH
- HeLa Cells MeSH
- Humans MeSH
- Liliaceae chemistry MeSH
- MCF-7 Cells MeSH
- Molecular Structure MeSH
- Drug Screening Assays, Antitumor MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amaryllidaceae Alkaloids MeSH
- Phenanthridines MeSH
- Antineoplastic Agents, Phytogenic MeSH
- lycorine MeSH Browser
In this study, the South African Amaryllid Boophone haemanthoides was examined for its phytochemical composition and cytotoxicity. In the process eight alkaloid structures, including the new compound distichaminol, were identified in bulb ethanolic extracts. Of the isolates, lycorine and distichamine exhibited strong activities against human acute lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7) and cervical adenocarcinoma (HeLa) cells with IC50S ranging from 1.8 to 9.2 microM.
