Alpha (α-) and beta (β-carboranyl-C-deoxyribosides: syntheses, structures and biological evaluation
Jazyk angličtina Země Francie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24980120
DOI
10.1016/j.ejmech.2014.06.005
PII: S0223-5234(14)00523-6
Knihovny.cz E-zdroje
- Klíčová slova
- Alkynes, Antitumor agents, Boron neutron capture therapy, Carboranes, Drug research,
- MeSH
- isomerie MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- nukleosidy chemická syntéza chemie farmakologie terapeutické užití MeSH
- rozpustnost MeSH
- sloučeniny boru chemie MeSH
- techniky syntetické chemie MeSH
- terapie metodou neutronového záchytu (bor-10) MeSH
- voda chemie MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- nukleosidy MeSH
- sloučeniny boru MeSH
- voda MeSH
The syntheses of the unprotected neutral closo-carboranyl-C-deoxyriboses, starting from anomeric mixture of 1-ethynyldeoxyriboses, and their corresponding open-cage nido-derivatives have been described. The structures of both the α- and β-anomers were confirmed by single-crystal X-ray diffraction. While limited water solubility of the neutral closo-anomers led to high cytotoxicity, their cesium salts (nido-species) exhibited higher water solubility leading to lower cytotoxicity. However, in vitro boron neutron capture therapy (BNCT) investigation using the murine squamous cell carcinoma (SCCVII) cell lines showed that there are no significant differences between the survival fractions of the two species.
Department of Chemistry and Biochemistry Northern Illinois University DeKalb IL 60115 2862 USA
Department of Inorganic Chemistry Charles University Prague Hlavova 8 153 00 Praha 2 Czech Republic
Department of Organic Chemistry Charles University Prague Hlavova 8 153 00 Praha 2 Czech Republic
Citace poskytuje Crossref.org
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