Medicinal applications of perfluoroalkylated chain-containing compounds
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
25078138
DOI
10.4155/fmc.14.53
Knihovny.cz E-resources
- MeSH
- Alkylation MeSH
- Fluorocarbons chemistry pharmacology MeSH
- Humans MeSH
- Drug Discovery * methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Fluorocarbons MeSH
Compounds with polyfluorinated molecular fragments possess unique properties associated with the presence of a large number of fluorine atoms that affect lipophilicity and conformational rigidity of the parent molecule along with other effects. The aim of this review is to provide an overview of synthesized compounds possessing perfluoroalkylated or polyfluorinated chains that have been tested for bioactivity or as potential drug candidates for the treatment of various diseases. As far as the length of the perfluoroalkylated chain is concerned the focus is centered on the compound bearing perfluoroethyl or tetrafluoroethyl as well as longer chains. The perfluoroalkylated compounds discussed are classified according to their biological activity.
References provided by Crossref.org
Cross-metathesis reaction of α- and β-vinyl C-glycosides with alkenes
