DISP3 promotes proliferation and delays differentiation of neural progenitor cells
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25281927
DOI
10.1016/j.febslet.2014.09.036
PII: S0014-5793(14)00713-3
Knihovny.cz E-zdroje
- Klíčová slova
- Cancer, Differentiation, Lipids, Neural cells, Proliferation,
- MeSH
- buněčná diferenciace * MeSH
- buněčné linie MeSH
- lidé MeSH
- membránové proteiny genetika metabolismus MeSH
- metabolismus lipidů MeSH
- mozek cytologie MeSH
- nervové kmenové buňky cytologie metabolismus MeSH
- proliferace buněk MeSH
- regulace genové exprese MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- DISP3 protein, human MeSH Prohlížeč
- membránové proteiny MeSH
DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation.
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