Quantitative analysis of drug losses administered via nasogastric tube--In vitro study
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
25437112
DOI
10.1016/j.ijpharm.2014.11.065
PII: S0378-5173(14)00880-1
Knihovny.cz E-zdroje
- Klíčová slova
- Dosage forms, Drug administration, Enteral feeding, Intensive care, Nasogastric tube,
- MeSH
- gastrointestinální intubace * MeSH
- léčivé přípravky aplikace a dávkování chemie MeSH
- léky s prodlouženým účinkem aplikace a dávkování chemie MeSH
- tablety aplikace a dávkování chemie MeSH
- tobolky aplikace a dávkování chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- léčivé přípravky MeSH
- léky s prodlouženým účinkem MeSH
- tablety MeSH
- tobolky MeSH
PURPOSE: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. METHODS: In vitro model was used. Five different administration methods (A-E) and six dosage forms (simple compressed tablets - T/S; film coated tablets - T/FC; enteric coated tablets - T/EC; capsules with powder filling - C/P; capsules containing extended release pellets - C/ER; capsules containing gastro-resistant pellets - C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial losses associated with each step of drug administration were also determined. RESULTS: Significant drug losses were measured (4-38%). Only methods A (crushing-beaker-syringe-water-NGT) and B (crushing-water-syringe-NGT) were suitable for administration of all tested dosage forms. Method B proved the most effective for all kinds of tablets and C/GR (p<0.05) and tended to be more effective also for C/ER (p=0.052) compared to method A. C/P showed minimal losses for both tested methods (B and E). Flushing of the drug through NGT causes major losses during drug administration compared to crushing and transfer (p<0.05). All methods for intact pellets (C-E) were found inappropriate for clinical practice due to NGT clogging. CONCLUSIONS: Choosing a suitable administration method can significantly affect the amount of drugs delivered through NGT.
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