High incidence of monozygotic twinning after assisted reproduction is related to genetic information, but not to assisted reproduction technology itself
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
25583445
DOI
10.1016/j.fertnstert.2014.12.098
PII: S0015-0282(14)02523-0
Knihovny.cz E-resources
- Keywords
- Monozygotic twins, assisted reproduction techniques, genetics, incidence, infertility,
- MeSH
- Reproductive Techniques, Assisted statistics & numerical data MeSH
- Adult MeSH
- Twins, Monozygotic * genetics statistics & numerical data MeSH
- Incidence MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Embryo Transfer methods statistics & numerical data MeSH
- Twinning, Monozygotic * genetics MeSH
- Pregnancy, Twin genetics statistics & numerical data MeSH
- Pregnancy MeSH
- Pregnancy Rate MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: To study the incidence of monozygotic twinning (MZT) in patients using in vitro fertilization, relative to their age, genetic background, ovarian function, and assisted reproductive techniques used. DESIGN: Analysis of a collected database. SETTING: Infertility treatment center. PATIENT(S): A total of 1,876 patients receiving infertility treatment between 2000 and 2012. Pregnancies with monozygotic twins (A: 23) were compared with deliveries of dizygotic twins (B: 423), singleton pregnancies (C: 880), and aborted pregnancies (D: 389). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): A genetic survey on multiple pregnancies in the extended family. Measures were micromanipulation technique, the length of embryo cultivation, type of cultivation media, basal follicle-stimulating hormone level, estradiol level on the day of human chorionic gonadotropin administration, number of oocytes, total consumption of gonadotropins, and consumption of gonadotropins needed for recovery of 1 oocyte. RESULT(S): No differences were found between the incidence of MZT in cycles that did vs. did not use micromanipulation techniques. In addition, the length of embryo cultivation or type of cultivation media used did not affect the results. Estradiol levels and implantation rates were significantly higher in group A. The incidence of MZT in families in group A was significantly higher than that in groups B and C. CONCLUSION(S): We propose that the high incidence of MZT in infertility-clinic patients is conditioned by hereditary factors, and good ovarian function only facilitates the expression. The resulting recommendation is that young women with a positive family history and good ovarian function undergo elective single-embryo transfer, and proper counseling is advisable.
Department of Midwifery Faculty of Health Sciences Palacky University Olomouc Olomouc Czech Republic
Fertimed Center for Reproductive Medicine and Infertility Olomouc Czech Republic
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