Manažment pacientov s kastračne rezistentným metastatickým karcinómom prostaty
[Management of patients with castration-resistant metastatic prostate cancer]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Review
PubMed
25692752
DOI
10.14735/amko201524
PII: 51229
- MeSH
- Androgen Antagonists therapeutic use MeSH
- Glucocorticoids therapeutic use MeSH
- Humans MeSH
- Prostatic Neoplasms, Castration-Resistant secondary therapy MeSH
- Orchiectomy MeSH
- Disease Progression MeSH
- Antineoplastic Agents therapeutic use MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Androgen Antagonists MeSH
- Glucocorticoids MeSH
- Antineoplastic Agents MeSH
Prostate cancer belongs to the most common malignant tumors in males. Almost in all patients in advanced stage, disease progression occurs despite of castration therapy. Initial treatment of metastatic disease is androgen deprivation therapy. In the case of castration-resistant disease development in asymptomatic patients, it is a combination of abiraterone acetate plus prednisone and in symptomatic patients docetaxel with prednisone are considered gold standards at the present time. The aim of therapy must be assurance of adequate quality of life, pain reduction and survival improvement. The paper presents an overview of current castration-resistant metastatic prostate cancer treatment.
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