Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25818093
DOI
10.1016/j.envpol.2015.03.024
PII: S0269-7491(15)00146-3
Knihovny.cz E-resources
- Keywords
- Air pollution, Carcinogenic PAH, DNA adducts, Dioxin-like activity, Oxidative damage, Particulate matter,
- MeSH
- DNA Adducts analysis chemistry MeSH
- Aerosols MeSH
- DNA chemistry MeSH
- Air Pollutants analysis toxicity MeSH
- Environmental Monitoring methods MeSH
- Oxidation-Reduction MeSH
- Particulate Matter analysis toxicity MeSH
- Polycyclic Aromatic Hydrocarbons analysis toxicity MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA Adducts MeSH
- Aerosols MeSH
- calf thymus DNA MeSH Browser
- DNA MeSH
- Air Pollutants MeSH
- Particulate Matter MeSH
- Polycyclic Aromatic Hydrocarbons MeSH
This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (dae, μm) coarse (1 < dae < 10), upper- (0.5 < dae < 1) and lower-accumulation (0.17 < dae < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 study days and contained ∼44% of total c-PAHs, while the ultrafine fraction contained only ∼11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative DNA damage is not induced by EOM.
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