UNLABELLED: A mixture of hyaluronan and iodine complex KI3 (Hyiodine®) has been developed to support wound healing. In this study, the effect of hyaluronan, KI3, and their combination on progression of wound healing in excision skin wounds in rats was determined. METHODS: To evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treat- ed wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using 131I as a radiolabel. RESULTS: Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. Even if wound therapy with Hyiodine resulted in systemic iodine uptake, the estimated iodine absorbed dose in human therapy is tolerable, and the theoretical risk of its systemic toxic effects is minimal. CONCLUSION: A hyaluronan-iodine hydrogel has a great potential for effective treatment of wounds. .

Faculty of Pharmacy in Hradec Kralove Charles University Prague Czech Republic

Faculty of Pharmacy in Hradec Kralove Charles University Prague Czech Republic; email

Laboratory of Wound Healing CPN Dolni Dobrouc Czech Republic

Laboratory of Wound Healing CPN Dolni Dobrouc Czech Republic; and National Institute of Rheumatic Diseases Piestany Slovak Republic

Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds