Survival after childhood cancer has improved substantially over recent decades. Although cancer in childhood is rare increasingly effective treatments have led to a growing number of long-term survivors. It is estimated that there are between 300,000 and 500,000 childhood cancer survivors in Europe. Such good survival prospects raise important questions relating to late effects of treatment for cancer. Research has shown that the majority will suffer adverse health outcomes and premature mortality compared with the general population. While chronic health conditions are common among childhood cancer survivors, each specific type of late effect is very rare. Long-term effects must be considered particularly when addressing complex multimodality treatments, and taking into account the interaction between aspects of treatment and genotype. The PanCare Network was set up across Europe in order to effectively answer many of these questions and thereby improve the care and quality of life of survivors. The need for a structured long-term follow-up system after childhood cancer has been recognised for some time and strategies for implementation have been developed, first nationally and then trans-nationally, across Europe. Since its first meeting in Lund in 2008, the goal of the PanCare Network has been to coordinate and implement these strategies to ensure that every European survivor of childhood and adolescent cancer receives optimal long-term care. This paper will outline the structure and work of the PanCare Network, including the results of several European surveys, the start of two EU-funded projects and interactions with relevant stakeholders and related projects.

2nd Department of Pediatrics Semmelweis University Budapest Hungary

Academic Medical Centre Amsterdam Netherlands

Austrian Childhood Cancer Organisation Vienna Austria

Boyne Research Institute Drogheda Ireland

Fondazione IRCCS Istituto Nazionale dei Tumori Milano Italy

Fondazione MBBM Monza Italy

German Childhood Cancer Registry University Medical Centre Mainz Germany

Great North Children's Hospital Newcastle University Newcastle UK

Great Ormond Street Hospital NHS Foundation Trust London UK

Institut Gustave Roussy Paris France

Institute of Oncology Ljubljana Slovenia

Institute of Primary and Community Care Lucerne Switzerland

Istituto Giannina Gaslini Genova Italy

Kinder und Jugendklinik Universität Erlangen CCC ErMN Erlangen Germany

Medical University of Graz Graz Austria

Skåne University Hospital Lund University Lund Sweden

St Anna Children's Hospital Vienna Austria

St Hilda's College Oxford UK

University Hospital Brno Brno Czech Republic

University of Birmingham Birmingham UK

University of Lucerne Lucerne Switzerland

Wroclaw University Wroclaw Poland

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