Genetic and phytochemical variability of six Teucrium arduini L. populations and their antioxidant/prooxidant behaviour examined by biochemical, macromolecule- and cell-based approaches
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25976825
DOI
10.1016/j.foodchem.2014.07.135
PII: S0308-8146(14)01183-2
Knihovny.cz E-resources
- Keywords
- Antioxidative/prooxidative activity, Cytotoxicity, Ethnopharmacology, Macromolecule bioassay, Polyphenols, Teucrium arduini L.,
- MeSH
- Antioxidants analysis chemistry MeSH
- Ethnopharmacology MeSH
- Phytochemicals analysis MeSH
- Phytotherapy MeSH
- Humans MeSH
- Plant Leaves chemistry MeSH
- Cell Line, Tumor MeSH
- Oxidants chemistry MeSH
- Teucrium chemistry genetics MeSH
- Reactive Oxygen Species analysis MeSH
- Plant Extracts chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Croatia MeSH
- Names of Substances
- Antioxidants MeSH
- Phytochemicals MeSH
- Oxidants MeSH
- Reactive Oxygen Species MeSH
- Plant Extracts MeSH
Teucrium arduini L., an Ilyric-Balcanic endemic species, has been reported for decades as a valuable plant used in traditional medicine for treating digestive disorders. The present study evaluated genetic and phytochemical variability of six T. arduini populations in order to determine factors that influence an accumulation of polyphenolic compounds. Results strongly suggest that a phytochemical variation was caused by environmental rather than genetic factors. T. arduini leaf extract from the locality Učka, which accumulated significantly more polyphenolic phytochemicals in comparison to others, showed antioxidant activity in DNA and lipid bioassays. Furthermore, the same extract exhibited prooxidant behaviour at protein level and induce formation of reactive oxygen species in human laryngeal carcinoma cells causing cytotoxic activity, in a dose dependent manner. All the results of the present study suggested that T. arduini extract could be responsible for antioxidative/prooxidative mechanisms and would help in determination of optimal conditions for their ethnopharmacological use.
Faculty of Food Technology and Biotechnology University of Zagreb Zagreb Croatia
Faculty of Pharmacy and Biochemistry University of Zagreb A Kovačića 1 10000 Zagreb Croatia
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