Genetic and phytochemical variability of six Teucrium arduini L. populations and their antioxidant/prooxidant behaviour examined by biochemical, macromolecule- and cell-based approaches
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25976825
DOI
10.1016/j.foodchem.2014.07.135
PII: S0308-8146(14)01183-2
Knihovny.cz E-zdroje
- Klíčová slova
- Antioxidative/prooxidative activity, Cytotoxicity, Ethnopharmacology, Macromolecule bioassay, Polyphenols, Teucrium arduini L.,
- MeSH
- antioxidancia analýza chemie MeSH
- etnofarmakologie MeSH
- fytonutrienty analýza MeSH
- fytoterapie MeSH
- lidé MeSH
- listy rostlin chemie MeSH
- nádorové buněčné linie MeSH
- oxidancia chemie MeSH
- ožanka chemie genetika MeSH
- reaktivní formy kyslíku analýza MeSH
- rostlinné extrakty chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Chorvatsko MeSH
- Názvy látek
- antioxidancia MeSH
- fytonutrienty MeSH
- oxidancia MeSH
- reaktivní formy kyslíku MeSH
- rostlinné extrakty MeSH
Teucrium arduini L., an Ilyric-Balcanic endemic species, has been reported for decades as a valuable plant used in traditional medicine for treating digestive disorders. The present study evaluated genetic and phytochemical variability of six T. arduini populations in order to determine factors that influence an accumulation of polyphenolic compounds. Results strongly suggest that a phytochemical variation was caused by environmental rather than genetic factors. T. arduini leaf extract from the locality Učka, which accumulated significantly more polyphenolic phytochemicals in comparison to others, showed antioxidant activity in DNA and lipid bioassays. Furthermore, the same extract exhibited prooxidant behaviour at protein level and induce formation of reactive oxygen species in human laryngeal carcinoma cells causing cytotoxic activity, in a dose dependent manner. All the results of the present study suggested that T. arduini extract could be responsible for antioxidative/prooxidative mechanisms and would help in determination of optimal conditions for their ethnopharmacological use.
Faculty of Food Technology and Biotechnology University of Zagreb Zagreb Croatia
Faculty of Pharmacy and Biochemistry University of Zagreb A Kovačića 1 10000 Zagreb Croatia
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