Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- Klíčová slova
- Advanced glycation end products, ferric reducing antioxidant power, histological chorioamnionitis, microbial invasion of the amniotic cavity, preterm delivery, rupture of membranes, thiobarbituric acid-reacting substances, total antioxidant capacity,
- MeSH
- antioxidancia metabolismus MeSH
- biologické markery krev MeSH
- chorioamnionitida krev MeSH
- dospělí MeSH
- fetální krev chemie MeSH
- gestační stáří MeSH
- látky reagující s kyselinou thiobarbiturovou metabolismus MeSH
- lidé MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- oxidační stres * MeSH
- předčasný odtok plodové vody krev MeSH
- produkty pokročilé glykace krev MeSH
- prospektivní studie MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antioxidancia MeSH
- biologické markery MeSH
- látky reagující s kyselinou thiobarbiturovou MeSH
- produkty pokročilé glykace MeSH
OBJECTIVE: To determine umbilical cord blood total antioxidant capacity (TAC), ferric reducing antioxidant power (FRAP), thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs) and markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and their associations with microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA), funisitis and selected aspects of short-term neonatal morbidity. MATERIALS AND METHODS: One hundred and sixty-five women with singleton pregnancies complicated by PPROM were included in this study. Blood samples were obtained by venipuncture from the umbilical cord vein after the delivery of the newborn. The umbilical cord blood concentrations of TAC, FRAP, TBARS and AGEs were measured. RESULTS: The presence of MIAC, HCA and funisitis did not show differences in the umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations. Positive correlations were found between the gestational age at sampling and umbilical cord blood TAC and AGEs concentrations (TAC: rho = 0.26; p = 0.001; AGEs: rho = 0.35; p < 0.0001). There was no association between umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations and selected aspects of short-term neonatal morbidity. CONCLUSIONS: Oxidative stress is associated with PPROM, as indicated by the presence of markers tested in the umbilical cord blood; however, the evaluated oxidative stress markers are not influenced by the presence of MIAC and/or HCA, and funisitis or subsequent development of selected aspects of short-term neonatal morbidity.
b Institute of Molecular Biomedicine Comenius University in Bratislava Bratislava Slovak Republic
c Center for Molecular Medicine Slovak Academy of Sciences Bratislava Slovak Republic
h Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
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