Brain activity on fMRI associated with urinary bladder filling in patients with a complete spinal cord injury
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
26445209
DOI
10.1002/nau.22901
Knihovny.cz E-resources
- Keywords
- functional magnetic resonance, neurogenic detrusor overactivity, urinary bladder, vagal nerve, visceral afferents,
- MeSH
- Afferent Pathways diagnostic imaging physiopathology MeSH
- Adult MeSH
- Blood Pressure physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Young Adult MeSH
- Urinary Bladder diagnostic imaging physiopathology MeSH
- Brain diagnostic imaging physiopathology MeSH
- Brain Stem diagnostic imaging physiopathology MeSH
- Vagus Nerve diagnostic imaging physiopathology MeSH
- Spinal Cord Injuries diagnostic imaging physiopathology MeSH
- Prosencephalon diagnostic imaging physiopathology MeSH
- Heart Rate physiology MeSH
- Urodynamics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain activation arising from anticipated extraspinal sensory pathways. METHODS: Fourteen patients ages 24-54 years were enrolled, all having experienced a complete SCI (ASIA A) at C7 to T5 an average of 17 months before study entry. Urodynamic equipment was used for repeated bladder filling and detrusor activity evaluation. All functional magnetic resonance imaging measurements were performed using a Siemens Trio 3T scanner with the GRE-EPI sequence (field of view = 192 × 192 mm, voxel 3 × 3 × 3 mm, TR/TE = 3000/30 ms, 45 slices). Nine hundred dynamic scans were acquired over 45 min. Statistical analysis was done in SPM8 using a general linear model. Statistics using t-tests were thresholded at P = 0.001. RESULTS: We excluded results from two patients because of activation artifacts. In 8 of 12 patients, significant brain activity was observed during urinary bladder filling. We found significant activation clusters at the nucleus of the solitary tract (NTS) (3/8), parabrachial nucleus (PBN) (4/8), hypothalamus (4/8), thalamus (6/8), amygdala (7/8), insular lobe (5/8), anterior cingulate gyrus (5/8), and prefrontal cortex (8/8). Activations in nuclei involved in afferents likely from the vagal nerve (NTS and PBN) correlated significantly with reported bladder sensations. CONCLUSIONS: These data suggest that extraspinal sensory pathways may develop following SCI and that vagal nerve may play a role in re-innervation of the urinary bladder. Neurourol. Urodynam. 36:155-159, 2017. © 2015 Wiley Periodicals, Inc.
Department of Surgical Studies Ostrava University Ostrava Czech Republic
Department of Urology Erasmus Medical Center Rotterdam the Netherlands
Department of Urology University Hospital Ostrava Czech Republic
Division of Urology University of Vermont Burlington Vermont
Spinal Cord Rehabilitation Unit Rehabilitation Center Kladruby Czech Republic
References provided by Crossref.org
