Natriuretic peptide resistance of mesenteric arteries in spontaneous hypertensive rat is alleviated by exercise
Language English Country Czech Republic Media print-electronic
Document type Journal Article
PubMed
26447511
DOI
10.33549/physiolres.933007
PII: 933007
Knihovny.cz E-resources
- MeSH
- Mesenteric Arteries drug effects physiology MeSH
- Atrial Natriuretic Factor pharmacology therapeutic use MeSH
- Hypertension drug therapy physiopathology therapy MeSH
- Physical Conditioning, Animal methods physiology MeSH
- Blood Pressure drug effects physiology MeSH
- Rats MeSH
- Drug Resistance MeSH
- Rats, Inbred SHR MeSH
- Rats, Inbred WKY MeSH
- Vasodilation drug effects physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Atrial Natriuretic Factor MeSH
Proximal resistance vessels, such as the mesenteric arteries, contribute substantially to the peripheral resistance. The reactivity of resistance vessels to vasoactive substance like natriuretic peptides plays an important role in the regulation of blood pressure. In current study, we investigated the reactivity of mesenteric arteries to atrial natriuretic peptide (ANP), a well known vasodilating factor, in spontaneously hypertensive rats (SHR), as well as the effects of exercise training on it. As a result, ANP-induced vasorelaxation was attenuated in SHR with significantly increased phosphodiesterase type 5 (PDE5), and decreased cGMP/ANP ratio, compared with WKY rats as control. Intriguingly, the decreased reactivity to ANP in SHR was markedly reversed by exercise training. In addition, ANP resistance of in vitro mesenteric arteries was diminished by sildenafil a potent selective inhibitor of PDE5. In conclusion, ANP resistance occurs in resistance vessels of SHR, suggesting predisposition to hypertension, which can be reversed by exercise.
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