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Genotype/allelic combinations as potential predictors of myocardial infarction

Nasibullin, Timur R
Author Nasibullin, Timur R Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation
Timasheva, Yanina R
Author Timasheva, Yanina R Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation
Sadikova, Regina I
Author Sadikova, Regina I Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation
Tuktarova, Ilsiyar A
Author Tuktarova, Ilsiyar A Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation
Erdman, Vera V
Author Erdman, Vera V Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation
Nikolaeva, Irina E
Author Nikolaeva, Irina E Republic Centre for Cardiology, Ufa, Russian Federation
Sabo, Jan
Author Sabo, Jan Department of Medical Physics and Biophysics, Faculty of Medicine, Pavol Jozef Safarik University, Trieda SNP 1, 040 11, Kosice, Slovak Republic
Kruzliak, Peter
Author Kruzliak, Peter Department of Medical Physics and Biophysics, Faculty of Medicine, Pavol Jozef Safarik University, Trieda SNP 1, 040 11, Kosice, Slovak Republic. peter.kruzliak@savba.sk 2nd Department of Internal Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic. peter.kruzliak@savba.sk Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. peter.kruzliak@savba.sk
Mustafina, Olga E
Author Mustafina, Olga E Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation

Molecular biology reports. 2016 Jan ; 43 (1) : 11-6. [epub] 20151212

Mol Biol Rep
ISSN 1573-4978 | 0301-4851
Source

Language English Country Netherlands Media print-electronic

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid26662939

PubMed 26662939
DOI 10.1007/s11033-015-3933-3
PII: 10.1007/s11033-015-3933-3
Knihovny.cz E-resources

Keywords
Genetic testing, Myocardial infarction, Risk prediction,
MeSH
Amidohydrolases genetics MeSH
Platelet Endothelial Cell Adhesion Molecule-1 genetics MeSH
Adult MeSH
Gene Frequency MeSH
Genetic Predisposition to Disease MeSH
Genetic Association Studies MeSH
Genetic Testing MeSH
Myocardial Infarction ethnology genetics MeSH
Polymorphism, Single Nucleotide MeSH
Middle Aged MeSH
Humans MeSH
Case-Control Studies MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Publication type
Journal Article MeSH
Geographicals
Russia MeSH
Names of Substances
Amidohydrolases MeSH
Platelet Endothelial Cell Adhesion Molecule-1 MeSH
dimethylargininase MeSH Browser

In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286). Using Markov chain Monte-Carlo method (APSampler), we found genotype combinations associated with increased and decreased risk of myocardial infarction. The most significant associations were detected for PECAM1*V/V + DDAH1*C (OR = 4.17 CI 1.56-11.15 Pperm = 0.005) SELE*C + VEGFA*I + CCL2*G + VCAM1*A + NOS3*D (OR = 2.74 CI 1.66-4.52 Pperm = 2.09 × 10(-5)), and VEGFA*D/D + CCL2*A + DDAH1*C (OR = 0.44 CI 0.28-0.7 Pperm = 7.89 × 10(-5)) genotype combinations.

2nd Department of Internal Medicine Faculty of Medicine Masaryk University Brno Czech Republic

Department of Medical Physics and Biophysics Faculty of Medicine Pavol Jozef Safarik University Trieda SNP 1 040 11 Kosice Slovak Republic

Department of Pharmacology and Toxicology Faculty of Pharmacy Comenius University Bratislava Slovak Republic

Institute of Biochemistry and Genetics Ufa Scientific Centre Russian Academy of Sciences Ufa Russian Federation

Republic Centre for Cardiology Ufa Russian Federation

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