Isolation, full genomic characterization and neutralization-based human seroprevalence of Medjerda Valley virus, a novel sandfly-borne phlebovirus belonging to the Salehabad virus complex in northern Tunisia
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26704069
DOI
10.1099/jgv.0.000389
Knihovny.cz E-resources
- MeSH
- Phylogeny MeSH
- Genome, Viral MeSH
- Insect Vectors virology MeSH
- Phlebotomus Fever epidemiology immunology transmission virology MeSH
- Humans MeSH
- Molecular Sequence Data MeSH
- Antibodies, Neutralizing immunology MeSH
- Phlebovirus classification genetics immunology isolation & purification MeSH
- Antibodies, Viral immunology MeSH
- Psychodidae virology MeSH
- Seroepidemiologic Studies MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Greece MeSH
- Tunisia epidemiology MeSH
- Names of Substances
- Antibodies, Neutralizing MeSH
- Antibodies, Viral MeSH
A new phlebovirus, Medjerda Valley virus (MVV), was isolated from one pool of Phlebotomus sp. (Diptera; Psychodidae) sandflies trapped in the vicinity of the Utique site, northern Tunisia. Genetic analysis based on complete coding of genomic sequences of the three RNA segments indicated that MVV is most closely related to members of the Salehabad virus species, where it is the fourth virus for which the complete sequence is available. A seroprevalence study was performed to search for neutralizing antibodies in human sera in the same region. The results demonstrate that in this area, MVV can readily infect humans despite low seroprevalence rates. Salehabad species viruses have generally been considered to be a group of viruses with little medical or veterinary interest. This view deserves to be revisited according to our human seroprevalence results, together with high animal infection rate of Adana virus and recent evidence of human infection with Adria virus in Greece. Further studies are needed to investigate the capacity of each specific member of the Salehabad virus species to cause human or animal diseases.
Department of Parasitology Faculty of Science Charles University Prague 2 128 44 Czech Republic
Faculty of Sciences of Bizerte University of Carthage Bizerte Tunisia
IHU Mediterranée Infection APHM Public Hospitals of Marseille 13005 Marseille France
Laboratory of Vector Ecology Institut Pasteur de Tunis Tunis Tunisia
Regional Health Department Governorate of Bizerte Bizerte Tunisia
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