• MeSH
• chirurgie operační * MeSH
• klimatické změny * MeSH
• lidé MeSH
• nezletilí * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• dopisy MeSH
• Geografické názvy
• Řecko MeSH

PURPOSE: An increasing number of patients with Duchenne muscular dystrophy (DMD) now have access to improved standard of care and disease modifying treatments, which improve the clinical course of DMD and extend life expectancy beyond 30 years of age. A key issue for adolescent DMD patients is the transition from paediatric- to adult-oriented healthcare. Adolescents and adults with DMD have unique but highly complex healthcare needs associated with long-term steroid use, orthopaedic, respiratory, cardiac, psychological, and gastrointestinal problems meaning that a comprehensive transition process is required. A sub-optimal transition into adult care can have disruptive and deleterious consequences for a patient's long-term care. This paper details the results of a consensus amongst clinicians on transitioning adolescent DMD patients from paediatric to adult neurologists that can act as a guide to best practice to ensure patients have continuous comprehensive care at every stage of their journey. METHODS: The consensus was derived using the Delphi methodology. Fifty-three statements were developed by a Steering Group (the authors of this paper) covering seven topics: Define the goals of transition, Preparing the patient, carers/parents and the adult centre, The transition process at the paediatric centre, The multidisciplinary transition summary - Principles, The multidisciplinary transition summary - Content, First visit in the adult centre, Evaluation of transition. The statements were shared with paediatric and adult neurologists across Central Eastern Europe (CEE) as a survey requesting their level of agreement with each statement. RESULTS: Data from 60 responders (54 full responses and six partial responses) were included in the data set analysis. A consensus was agreed across 100% of the statements. CONCLUSIONS: It is hoped that the findings of this survey which sets out agreed best practice statements, and the transfer template documents developed, will be widely used and so facilitate an effective transition from paediatric to adult care for adolescents with DMD.

• MeSH
• delfská metoda * MeSH
• dítě MeSH
• dospělí MeSH
• Duchennova muskulární dystrofie * terapie   MeSH
• konsensus MeSH
• lidé MeSH
• mladiství MeSH
• neurologové MeSH
• přechod k lékaři pro dospělé MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Evropa MeSH
• Izrael MeSH
• Řecko MeSH

BACKGROUND: Psychotic-like experiences (PLEs) are subtle, subclinical perturbations of perceptions and thoughts and are common in the general population. Their characterisation and unidimensionality are still debated. METHODS: This study was conducted by the Electronic-halluCinations-Like Experiences Cross-culTural International Consortium (E-CLECTIC) and aimed at measuring the Community Assessment of Psychic Experiences (CAPE) factorial structure across five European countries (Belgium; Czech Republic, Germany; Greece, and Spain) and testing the adequacy of the unidimensional polytomous Rasch model of the tool via Partial Credit Model (PCM) of the CAPE to detect people with a high risk for developing psychosis. RESULTS: The sample included 1461 participants from the general population. The factorial analysis confirmed the best fit for the bifactor implementation of the three-factor model, including the positive, negative and depressive dimensions and a general factor. Moreover, the unidimensional polytomous Rasch analysis confirmed that CAPE responses reflected one underlying psychosis proneness. CONCLUSIONS: The study proved that the CAPE measures a single latent dimension of psychosis-proneness. The CAPE might help locate and estimate psychosis risk and can be used as a screening tool in primary care settings/education settings.

• MeSH
• dospělí MeSH
• faktorová analýza statistická MeSH
• halucinace diagnóza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• psychiatrické posuzovací škály normy   MeSH
• psychometrie * normy   MeSH
• psychotické poruchy * diagnóza   psychologie   MeSH
• srovnání kultur MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Belgie MeSH
• Česká republika MeSH
• Evropa MeSH
• Německo MeSH
• Řecko MeSH
• Španělsko MeSH

• MeSH
• dospělí MeSH
• fenotyp * MeSH
• frekvence genu MeSH
• genetická predispozice k nemoci MeSH
• genetické asociační studie MeSH
• HLA antigeny genetika   MeSH
• jednonukleotidový polymorfismus * MeSH
• lidé středního věku MeSH
• lidé MeSH
• sarkoidóza * genetika   MeSH
• studie případů a kontrol MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• dopisy MeSH
• Geografické názvy
• Řecko MeSH

BACKGROUND: This paper details the results of an evaluation of the level of consensus amongst clinicians on the use of ataluren in both ambulatory and non-ambulatory patients with nonsense mutation Duchenne muscular dystrophy (nmDMD). The consensus was derived using a modified Delphi methodology that involved an exploration phase and then an evaluation phase. METHODS: The exploration phase involved 90-minute virtual 1:1 interviews of 12 paediatric neurologists who cared for 30-120 DMD patients each and had patient contact every one or two weeks. The respondents managed one to ten nmDMD patients taking ataluren. The Discussion Guide for the interviews can be viewed as Appendix A. Following the exploration phase interviews, the interview transcripts were analysed by an independent party to identify common themes, views and opinions and developed 43 draft statements that the Steering Group (authors) reviewed, refined and endorsed a final list of 42 statements. Details of the recruitment of participants for the exploration and evaluation phases can be found under the Methods section. RESULTS: A consensus was agreed (> 66% of respondents agreeing) for 41 of the 42 statements using results from a consensus survey of healthcare professionals (n = 20) experienced in the treatment of nmDMD. CONCLUSIONS: The statements with a high consensus suggest that treatment with ataluren should be initiated as soon as possible to delay disease progression and allow patients to remain ambulatory for as long as possible. Ataluren is indicated for the treatment of Duchenne muscular dystrophy that results from a nonsense mutation in the dystrophin gene, in ambulatory patients aged 2 years and older (see Summary of Product Characteristics for each country).

• MeSH
• dítě MeSH
• Duchennova muskulární dystrofie * genetika   terapie   MeSH
• dystrofin genetika   MeSH
• konsensus MeSH
• lidé MeSH
• nesmyslný kodon MeSH
• oxadiazoly * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Izrael MeSH
• Řecko MeSH
• Švédsko MeSH
• východní Evropa MeSH

Background: In Greek scientific literature, no other studies using emotional intelligence as a personal trait were found. Objective: The aim of this study was to explore the validity and reliability of the Trait Emotional Intelligence Questionnaire - Short Form in a Greek educational context. The internal consistency as well as the levels of emotional intelligence, along with the gender as a factor that differentiates emotional intelligence have also been examined. Methods: The sample of the study consisted of 306 (for exploratory factor analysis) and 415 (for confirmatory factor analysis) students who attended the 7th, 8th, and 9th grades of high school. The selection of the sample was randomly performed. The scale consists of 30 questions and four factors. The statistical analysis of the data included descriptive statistics, exploratory and confirmatory factor analysis, reliability analysis using Cronbach's α and discriminant/convergent validity, and t-test for independent samples. Results: The results of the confirmatory factor analysis demonstrated that the hypothesized model produced a significant χ2 (1026.58), normed fit index (.96) and comparative fit index (.97). The root mean square error of approximation (.78) was also considered to assess the degree extent to which the model of fit of. Composite reliability (≥ .948) and average variance extracted (≥ .751) of all dimensions of the Trait Emotional Intelligence Questionnaire - Short Form demonstrated an acceptable reliability coefficient. Conclusions: From the analysis of the results, we came to the following conclusions. The Trait Emotional Intelligence Questionnaire - Short Form constitutes an instrument credible enough to measure the emotional intelligence of high school male and female students. Gender is a differentiation factor for Total emotional intelligence, Self-control, and Well-being factors.

• MeSH
• analýza dat MeSH
• emoční inteligence * MeSH
• lidé MeSH
• mladiství MeSH
• pohlaví MeSH
• průzkumy a dotazníky MeSH
• psychická pohoda psychologie   MeSH
• sebekontrola psychologie   MeSH
• studenti psychologie   MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• Publikační typ
• klinická studie MeSH
• Geografické názvy
• Řecko MeSH

AIM: The aim of this study was to investigate the association of serum total Hcy (tHcy) levels with various demographic, clinical and genetic characteristics in healthy Greek adults. METHODS: Anthropometric characteristics (height, weight), systolic and diastolic blood pressure, complete blood count and biochemical assessments, were recorded and measured among 383 Greek adults (199 men). Serum folate, Cobalamin (Cbl) and tHcy levels were determined using immunoassays methods. The MTHFR C677T and A1298C gene polymorphisms were genotyped using polymerase chain reaction and reverse hybridization. RESULTS: MTHFR C677T gene polymorphism, serum folate and Cbl levels were correlated with serum tHcy levels independently. The individuals with 677TT genotype had significantly higher serum tHcy levels than individuals with 677 CC or CT genotypes. Regarding the MTHFR C677T gene polymorphism, the existence of the T allele was associated with statistically significantly lower serum folate and higher serum tHcy levels than C allele. Regarding the MTHFR A1298C gene polymorphism, the existence of the C allele was associated with statistically significant lower serum tHcy levels than A allele. Furthermore, there was no significant correlation between the serum tHcy levels and demographic (except age) or clinical characteristics (sex, BMI, smoking status, SBP, DBP, HGB, HCT, TC, TG, HDL-C, LDL-C, TC/HDL-C). CONCLUSIONS: Serum tHcy levels are influenced by the existence of MTHFR C677T gene polymorphism (mainly 677TT genotype), serum folate and Cbl levels. Individuals with hyperhomocysteinemia should be further investigated for the existence of MTHFR C677T gene polymorphism, with the aim to determine the suitable treatment.

• MeSH
• demografie MeSH
• dospělí MeSH
• genotyp MeSH
• homocystein genetika   MeSH
• kyselina listová * MeSH
• lidé MeSH
• methylentetrahydrofolátreduktasa (NADPH2) genetika   MeSH
• polymorfismus genetický * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Řecko MeSH

The incidence and mortality of traumatic brain injuries (TBI) among non-residents to countries where they occur remains unknown, warranting epidemiological research. Epidemiological data are key to inform prevention and public health policies related to TBI, as well as to help promote safe travelling practice. The aim of this study was to analyse the epidemiological patterns of TBI-related deaths among residents and non-residents in 30 European countries in 2015 using standardised European level data on causes of death. A large-scale cross-sectional study analysing TBI-related deaths in 30 European countries in 2015 among residents and non-residents to the country of occurrence of the death was conducted. Data from death certificates collected on European level by Eurostat were used to calculate the numbers of TBI-related deaths and estimate crude and age-standardised mortality rates. Rates were stratified by country, sex, age-group and by resident status. External causes of the injury were determined using the provided ICD-10 codes. 40,087 TBI-related deaths were identified; overall about 3% occurred among non-residents with highest proportions in Turkey (11%), Luxembourg (9%) and Cyprus (5%). Taking into account tourism intensity in the countries, Bulgaria, Greece and Austria showed highest rates of TBI-related deaths in non-residents: 0.7,0.5 and 0.5 per million overnight stays, respectively. The pooled age-standardised TBI-related mortality in non-residents was 0.2 (95% CI 0.1-0.3), among residents 10.4 (95% CI 9.4-11.5) per 100,000. In non-residents, TBI-related deaths were shifted to younger populations (86% in < 35 years); in non-residents 78% were 15-64 years old. Falls were predominant among residents (47%), and traffic accidents among non-residents (36%). Male:female ratio was higher among non-residents (3.9), compared to residents (2.1). Extrapolating our findings, we estimate that annually 1022 TBI-related deaths would occur to non-residents in the EU-27 + UK and 1488 in Europe as a continent. We conclude, that the primary populations at risk of TBI-related deaths in European countries differ in several characteristics between residents and non-residents to the country of the occurrence of death, which warrants for different approaches in prevention and safety promotion. Our findings suggest that TBI occurring in European countries among non-residents present a problem worthy of attention from public health and travel medicine professionals and should be further studied.

• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• průřezové studie MeSH
• traumatické poranění mozku * etiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Kypr MeSH
• Rakousko MeSH
• Řecko MeSH

• MeSH
• absolventi zahraničních lékařských škol * MeSH
• biologická terapie MeSH
• kožní nemoci * etiologie   terapie   MeSH
• studium lékařství MeSH
• Publikační typ
• rozhovory MeSH
• Geografické názvy
• Řecko MeSH

Paros je s rozlohou necelých 200 km2 třetím největším ostrovem v Kykladech (asi 15 000 stálých obyvatel). Ačkoliv je tento ostrov velmi oblíbenou destinací nejen v létě, kdy zde tráví volno mnoho Řeků i cizinců, dostupnost zdravotní péče ani na začátku 21. století stále není ideální, zejména z pohledu obyvatel vnitrozemského státu s hustou sítí zdravotnických zařízení. Článek se věnuje některým aspektům historie medicíny a dostupnosti lékařské péče na Paru od 20. století až dosud. Zaměřuje se zejména na osobu a činnost místního rodáka, doktora jménem Georgios Patelis (1910–1991), který od čtyřicátých do konce sedmdesátých let 20. století prováděl na ostrově veškerou zdravotní péči jako jediný graduovaný lékař. Vzhledem k jeho zásluhám o zdravotnictví i celkový rozvoj ostrova je mu v centru Parikie věnováno malé Lékařské muzeum, kde o doktorův odkaz pečuje jeho dcera Katerina. Druhá část článku popisuje historii lékařské péče na Paru a obecně na celých Kykladech v posledních 50 letech.

Paros is with the area of almost 200 km2 the third largest island in the Cyclades (ca. 15.000 permanent inhabitants). Although this island is very favourite summer destination for many Greeks and foreigners, the availability of medical care is not ideal here even at the beginning of 21st century, especially from the perspective of the citizens of the central European inland state with a dense network of medical facilities. The paper is presenting some aspects of medical history and availability of medical care on Paros from 20th century until the present day. It is focusing mostly on the life and work of the local native, doctor Georgios Patelis (1910–1991), who worked from 1940s until the end of 1970s as the only graduated medical practitioner on the island. With respect to his credits for the public health and the general development of the island a small Medical museum was dedicated to him in the centre of Parikia, where his daughter Katerina is caring for his memory and legacy. The second part of this paper describes the history of medical care on Paros – and in general, on the Cyclades – in the last 50 years.

• MeSH
• dějiny 20. století MeSH
• lidé MeSH
• poskytování zdravotní péče * dějiny   MeSH
• primární zdravotní péče dějiny   MeSH
• Check Tag
• dějiny 20. století MeSH
• lidé MeSH
• Publikační typ
• biografie MeSH
• historické články MeSH
• Geografické názvy
• Řecko MeSH