Fekální bakterioterapie v léčbě rekurentní kolitidy způsobené Clostridium difficile na Klinice infekčních chorob Fakultní nemocnice Brno v letech 2010-2014 - prospektivní studie
[Fecal bacteriotherapy for the treatment of recurrent Clostridium difficile colitis used in the Clinic of Infectious Diseases of the University Hospital Brno in 2010-2014 - a prospective study]
Language Czech Country Czech Republic Media print
Document type Journal Article
PubMed
26795227
PII: 57188
- Keywords
- Clostridium difficile colitis - recurrence - fecal bacteriotherapy.,
- MeSH
- Ambulatory Care Facilities MeSH
- Biological Therapy * MeSH
- Clostridioides difficile physiology virology MeSH
- Adult MeSH
- Feces microbiology MeSH
- Clostridium Infections microbiology therapy MeSH
- Colitis microbiology therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Hospitals, University statistics & numerical data MeSH
- Prospective Studies MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czech Republic MeSH
INTRODUCTION: The aim of the study is to assess the efficacy of fecal bacteriotherapy in the treatment of Clostridium difficile colitis. MATERIALS AND METHODS: A prospective study of fecal bacteriotherapy in 80 adult patients hospitalized in the Clinic of Infectious Diseases, University Hospital Brno between 1 January 2010 and 31 December 2014. RESULTS: During the study period, 80 patients were treated with fecal bacteriotherapy. The majority of the study group received fecal bacteriotherapy via a nasojejunal tube (n=78) and two patients via a rectal enema. Six patients were instilled with 20 g of feces, with a success rate of 50 %. The outcomes of nine patients were unevaluable. In the rest of 65 patients, the success rate with 40 g of feces was 83.1 %. There were no severe adverse events or mortality associated with fecal bacteriotherapy. CONCLUSIONS: Fecal bacteriotherapy is a safe and effective treatment modality in Clostridium difficile colitis.
