Venturing into the New Science of Nucleases
Language English Country United States Media print
Document type Journal Article, Comment
Grant support
P30 CA077598
NCI NIH HHS - United States
R01 AR063070
NIAMS NIH HHS - United States
PubMed
27012560
PubMed Central
PMC5320895
DOI
10.1016/j.jid.2016.01.021
PII: S0022-202X(16)00450-4
Knihovny.cz E-resources
- MeSH
- Epidermolysis Bullosa Dystrophica genetics MeSH
- Collagen Type VII genetics MeSH
- Humans MeSH
- DNA Repair * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Names of Substances
- Collagen Type VII MeSH
Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.
Department of Pediatrics University of Minnesota Minneapolis Minnesota USA
Genetic Skin Disease Group St John's Institute of Dermatology London UK
Univerzita Karlova Praha 2 lekarska fakulta Medicine Prague Czech Republic
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