Effects of novel maleimide derivatives on cell cultures with different properties
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
27139892
DOI
10.1007/s10561-016-9558-5
PII: 10.1007/s10561-016-9558-5
Knihovny.cz E-resources
- Keywords
- Anticancer drug, Antiproliferative effects, Cell cultures, Maleimide derivates,
- MeSH
- Cells cytology drug effects MeSH
- Endothelial Cells cytology drug effects MeSH
- Fibroblasts cytology drug effects MeSH
- HEK293 Cells MeSH
- HeLa Cells MeSH
- Inhibitory Concentration 50 MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Maleimides chemistry pharmacology MeSH
- Mesenchymal Stem Cells cytology drug effects MeSH
- MCF-7 Cells MeSH
- Multipotent Stem Cells cytology drug effects MeSH
- Umbilical Cord cytology MeSH
- Cell Line, Transformed MeSH
- Cell Shape drug effects MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- maleimide MeSH Browser
- Maleimides MeSH
The paper is focused on pilot study of effects of novel synthetic protein kinase inhibitors-maleimide derivatives in different concentrations on normal, transformed and multipotent cell lines. Influence on cell proliferation and morphological characteristics has been demonstrated. The chosen agents cause antiproliferative effect on transformed cells and are not cytotoxic to normal cell lines. Moreover, different maleimide derivatives' effects on multipotent cells in attached and floating states has been shown. Described results can be used for further research of the maleimide derivatives as antitumor agents.
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