Alemtuzumab improves quality-of-life outcomes compared with subcutaneous interferon beta-1a in patients with active relapsing-remitting multiple sclerosis
Language English Country Great Britain, England Media print-electronic
Document type Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial
PubMed
27885061
DOI
10.1177/1352458516677589
PII: 1352458516677589
Knihovny.cz E-resources
- Keywords
- Alemtuzumab, CD52 antigen, disease-modifying therapy, interferon beta-1a, multiple sclerosis, quality of life,
- MeSH
- Alemtuzumab therapeutic use MeSH
- Adult MeSH
- Immunologic Factors therapeutic use MeSH
- Interferon beta-1a therapeutic use MeSH
- Quality of Life * MeSH
- Middle Aged MeSH
- Humans MeSH
- Multiple Sclerosis, Relapsing-Remitting drug therapy MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial, Phase III MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Alemtuzumab MeSH
- Immunologic Factors MeSH
- Interferon beta-1a MeSH
BACKGROUND: Alemtuzumab was superior on clinical and magnetic resonance imaging (MRI) outcomes versus subcutaneous interferon beta-1a in phase 3 trials in patients with relapsing-remitting multiple sclerosis. OBJECTIVE: To examine quality-of-life (QoL) outcomes in the alemtuzumab phase 3 trials. METHODS: Patients who were treatment naive (Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis I [CARE-MS I]) or had an inadequate response to prior therapy (CARE-MS II) received annual courses of alemtuzumab 12 mg/day at baseline (5 days) and Month 12 (3 days) or subcutaneous interferon beta-1a 44 µg three times/week. QoL was measured every 6 or 12 months using Functional Assessment of Multiple Sclerosis (FAMS), European Quality of Life-5 Dimensions (EQ-5D) and its visual analog scale (EQ-VAS), and 36-Item Short-Form Survey (SF-36). RESULTS: Statistically significant improvements from baseline with alemtuzumab were observed on all three QoL instruments at the earliest post-baseline assessment and sustained through Year 2. Statistically significant greater QoL improvements over subcutaneous interferon beta-1a were seen at all time points in CARE-MS II with FAMS, EQ-VAS and SF-36 physical component summary, and in CARE-MS I with FAMS. CONCLUSION: Patients treated with alemtuzumab had improvements in physical, mental, and emotional QoL regardless of treatment history. Improvements were significantly greater with alemtuzumab versus subcutaneous interferon beta-1a on both disease-specific and general measures of QoL.
Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK
Department of Neurology Hospital Universitario Quirónsalud Madrid Spain
MS Center Department of Neurology 1st Faculty of Medicine Charles University Prague Czech Republic
Multiple Sclerosis Center of Greater Washington Vienna VA USA
Sanofi Genzyme Cambridge MA USA
Virginia Mason Hospital and Seattle Medical Center Seattle WA USA
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