Hypoxic-ischemic encephalopathy (HIE) is one of the leading pediatric neurological conditions causing long-term disabilities and socio-economical burdens. Nearly 20-50 % of asphyxiated newborns with HIE die within the newborn period and another third will develop severe health consequences and permanent handicaps. HIE is the result of severe systemic oxygen deprivation and reduced cerebral blood flow, commonly occurring in full-term infants. Hypoxic-ischemic changes trigger several molecular and cellular processes leading to cell death and inflammation. Generated reactive oxygen species attack surrounding cellular components resulting in functional deficits and mitochondrial dysfunction. The aim of the present paper is to review present knowledge about the pathophysiology of perinatal hypoxic-ischemic encephalopathy, especially with respect to novel treatment strategies and biomarkers that might enhance early detection of this disorder and thus improve the general outcome of patients.

Institute of Physiology 1st Faculty of Medicine Charles University Prague Czech Republic; Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic

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Serum biomarkers of hypoxic-ischemic brain injury

Impact of prenatal hypoxia on the development and behavior of the rat offspring

Neonatal hypoxic-ischemic brain injury leads to sex-specific deficits in rearing and climbing in adult mice

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Impact of perinatal hypoxia on the developing brain

Early postnatal hypoxia induces behavioral deficits but not morphological damage in the hippocampus in adolescent rats