Perinatal hypoxic-ischemic damage: review of the current treatment possibilities
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
33464921
PubMed Central
PMC8603715
DOI
10.33549/physiolres.934595
PII: 934595
Knihovny.cz E-zdroje
- MeSH
- erythropoetin terapeutické užití MeSH
- hypoxie komplikace farmakoterapie patofyziologie MeSH
- látky tlumící činnost CNS terapeutické užití MeSH
- lidé MeSH
- melatonin terapeutické užití MeSH
- mozková hypoxie a ischemie farmakoterapie etiologie patofyziologie MeSH
- novorozenec MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- erythropoetin MeSH
- látky tlumící činnost CNS MeSH
- melatonin MeSH
Neonatal hypoxic-ischemic encephalopathy is a disorder with heterogeneous manifestation due to asphyxia during perinatal period. It affects approximately 3-12 children per 1000 live births and cause death of 1 million neonates worldwide per year. Besides, motor disabilities, seizures, impaired muscle tone and epilepsy are few of the consequences of hypoxic-ischemic encephalopathy. Despite an extensive research effort regarding various treatment strategies, therapeutic hypothermia with intensive care unit supportive treatment remains the only approved method for neonates who have suffered from moderate to severe hypoxic-ischemic encephalopathy. However, these protocols are only partially effective given that many infants still suffer from severe brain damage. Thus, further research to systematically test promising neuroprotective treatments in combination with hypothermia is essential. In this review, we discussed the pathophysiology of hypoxic-ischemic encephalopathy and delved into different promising treatment modalities, such as melatonin and erythropoietin. However, preclinical studies and clinical trials are still needed to further elucidate the mechanisms of action of these modalities.
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The effect of sulforaphane on perinatal hypoxic-ischemic brain injury in rats