PURPOSE: solitary fibrous tumors (SFT) represent a heterogeneous group of primary pleural neoplasms with a low incidence rate and of which the biological origin, which consists of mesenchymal cells, is uncertain. METHODS: The authors present herewith a retrospective analysis of 22 patients with SFTs who were diagnosed and surgically treated between the years 2000-2015. The preoperative tumors were successfully verified morphologically by transthoracic core needle biopsy under CT control in 27.3% of patients. Surgical approaches were either posterolateral thoracotomy or videothoracoscopy. The follow-up median was 45 months (range 1-188 months). RESULTS: Twenty tumors were surgically removed radically, two tumors were found to be unresectable due to the considerable tumor size. From histological point of view 81.8% of tumors were SFT with low malignant potential, 18.2% of tumors with high malignant potential. Despite the radical extirpation of the SFT, it relapsed in two patients. CONCLUSION: The gold standard of SFT treatment is radical surgical removal; however, patients at risk of recurrence require additional follow-ups. The results of adjuvant therapy in recurrent and malignant forms of SFTs are the subject of discussion and further study.

Clinic of Surgery Faculty of Medicine in Pilsen Charles University Prague University Hospital Pilsen Pilsen Czech Republic

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Abu Arab W. Solitary fibrous tumours of the pleura. Eur J Cardiothorac Surg 2012; 41: 587-97. PubMed

Liu J, Cai C, Wang D, et al. Video-assisted thoracoscopic surgery (VATS) for patients with solitary fibrous tumors of the pleura. J Thorac Oncol 2010; 5: 240-3. PubMed

El-Naggar AK, Ro JY, Ayala AG, et al. Localized fibrous tumor of the serosal cavities. Immunohistochemical, electron-microscopic, and flow-cytometric DNA study. Am J Clin Pathol 1989; 92: 561-5. PubMed

Magdeleinat P, Alifano M, Petino A, et al. Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome. Eur J Cardiothorac Surg 2002; 21: 1087-93. PubMed

Szkorupa M, Klein J, Bohanes T, et al. [Solitary fibrous tumor of pleural cavity]. Rozhl Chir 2010; 89: 750-3. (in Czech) PubMed

Leng XF, Xian L, Qin JJ, et al. Malignant solitary fibrous tumor of pleura accompanied with first symptoms of chest pain and hemoptysis: a case report. Ann Thorac Cardiovasc Surg 2012; 18: 251-5. PubMed

Rena O, Filosso PL, Papalia E, et al. Solitary fibrous tumour of the pleura: surgical treatment. Eur J Cardiothorac Surg 2001; 19: 185-9. PubMed

Lococo F, Cesario A, Cardillo G, et al. Malignant solitary fibrous tumors of the pleura: retrospective review of a multicenter series. J Thorac Oncol 2012; 7: 1698-706. PubMed

Sakurai H, Tanaka W, Kaji M, et al. Intrapulmonary localized fibrous tumor of the lung: a very unusual presentation. Ann Thorac Surg 2008; 86: 1360-2. PubMed

Tastepe I, Alper A, Ozaydin HE, et al. A case of multiple synchronous localized fibrous tumor of the pleura. Eur J Cardiothorac Surg 2000; 18: 491-4. PubMed

Dynes MC, White EM, Fry WA, et al. Imaging manifestations of pleural tumors. Radiographics 1992; 12: 1191-201. PubMed

Thakkar RG, Shah S, Dumbre A, et al. Giant solitary fibrous tumour of pleura -an uncommon intrathoracic entity- a case report and review of the literature. Ann Thorac Cardiovasc Surg 2011; 17: 400-3. PubMed

Abe M, Nomori H, Fukazawa M, et al. Giant solitary fibrous tumor of the pleura causing respiratory insufficiency: report of 3 cases. Ann Thorac Cardiovasc Surg 2014; 20: 441-4. PubMed

Enon S, Kilic D, Yuksel C, et al. Benign localized fibrous tumor of the pleura: report of 25 new cases. Thorac Cardiovasc Surg 2012; 60: 468-73. PubMed

Liu CC, Wang HW, Li FY, et al. Solitary fibrous tumors of the pleura: clinicopathological characteristics, immunohistochemical profiles, and surgical outcomes with long-term follow-up. Thorac Cardiovasc Surg 2008; 56: 291-7. PubMed

Maeda S, Sugita M, Sagawa M, et al. Solitary fibrous tumor of the pleura suddenly induced hypoglycemia before surgical treatment. Ann Thorac Cardiovasc Surg 2011; 17: 293-6. PubMed

Li Z, Wang J, Zhu Q, et al. Huge solitary fibrous tumor of the pleura with hypoglycemia and hypokalemia: a case report. Ann Thorac Cardiovasc Surg 2014; 20: 165-8. PubMed

Usami N, Iwano S, Yokoi K. Solitary fibrous tumor of the pleura: evaluation of the origin with 3D CT angiography. J Thorac Oncol 2007; 2: 1124-5. PubMed

Yao H, Hu Z, Shi H, et al. Intrathoracic solitary fibrous tumor: a report of 3 cases and review of the literature. Chinese-German J Clin Oncol 2012; 11: 660-4.

Goodlad JR, Fletcher CD. Solitary fibrous tumour arising at unusual sites: analysis of a series. Histopathology 1991; 19: 515-22. PubMed

Orki A, Kosar A, Akin O, et al. Solitary fibrous tumor of the pleura. Thorac Cardiovasc Surg 2008; 56: 287-90. PubMed

Boddaert G, Guiraudet P, Grand B, et al. Solitary fibrous tumors of the pleura: a poorly defined malignancy profile. Ann Thorac Surg 2015; 99: 1025-31. PubMed

Ozeki N, Kawaguchi K, Taniguchi T, et al. Primary pulmonary solitary fibrous tumour with brain metastases. Eur J Cardiothorac Surg 2014; 45: 386-8. PubMed

Cardillo G, Facciolo F, Cavazzana AO, et al. Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients. Ann Thorac Surg 2000; 70: 1808-12. PubMed

Bylicki O, Rouvière D, Cassier P, et al. Assessing the multimodal management of advanced solitary fibrous tumors of the pleura in a routine practice setting. J Thorac Oncol 2015; 10: 309-15. PubMed