Persistence in the treatment of overactive bladder syndrome (OAB) with mirabegron in a multicenter clinical study
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu klinická studie, časopisecké články, multicentrická studie
PubMed
28073038
DOI
10.1016/j.ejogrb.2016.12.030
PII: S0301-2115(16)31092-2
Knihovny.cz E-zdroje
- Klíčová slova
- Antimuscarinic, Mirabegron, Overactive bladder, Persistence,
- MeSH
- acetanilidy terapeutické užití MeSH
- agonisté beta-3-adrenergních receptorů terapeutické užití MeSH
- dospělí MeSH
- hodnocení adherence k farmakoterapii * MeSH
- hyperaktivní močový měchýř farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- thiazoly terapeutické užití MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinická studie MeSH
- multicentrická studie MeSH
- Názvy látek
- acetanilidy MeSH
- agonisté beta-3-adrenergních receptorů MeSH
- mirabegron MeSH Prohlížeč
- thiazoly MeSH
OBJECTIVE: The objective of this project was to evaluate treatment persistence in patients being treated for overactive bladder syndrome (OAB) with mirabegron, employing clinical follow-up in a prospective, multicenter study. STUDY DESIGN: This is an analysis of patients who started treatment with mirabegron between May and September 2014 and were evaluated 1year after treatment commenced. During this evaluation we determined how many patients stopped treatment and established their reasons for discontinuation. RESULTS: 206 patients being treated for OAB with mirabegron were evaluated a year after starting treatment. It emerged that 60 patients (29.1%) had discontinued the treatment, citing the following reasons: 24/60 insufficient treatment efficacy, 26/60 other reasons, while 10 members of the group discontinued treatment because of side effects. 75 out of 206 patients were ≤60 years old and 28% terminated the study prematurely: 131 out of 206 were >60years old and 29.2% terminated the study prematurely. In the group of patients without previous OAB treatment 35.7% discontinued treatment with mirabegron, while 28.1% of patients with previous anticholinergic treatment discontinued treatment. CONCLUSION: In our clinical prospective multicenter study, persistence in treatment with mirabegron reached a figure of 71%.
Department of Urology Thomayer Hospital Prague Czechia
Department of Urology University Hospital in Ostrava Czechia
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