Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. The role of adjuvant radiotherapy has not been well defined, although there is an agreement that it should be considered in advanced-stage or high-grade disease. This review considers only the most common malignant salivary neoplasms of the larynx with a focus on clinical management of these tumors.

Coordinator of the International Head and Neck Scientific Group Padua Italy

Department of Anatomic Pathology Hospital Clinic University of Barcelona Barcelona Spain

Department of Biomedical Sciences and Medicine University of Algarve Faro Portugal

Department of Otolaryngology Hospital Santa Creu i Sant Pau Barcelona Spain

Department of Otolaryngology Hospital Universitario Central de Asturias Oviedo Spain

Department of Pathology Faculty of Medicine in Plzen Charles University Prague Plzen Czech Republic

Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA

Department of Pathology University of Arkansas for Medical Sciences Little Rock AR USA

Department of Radiation Oncology Institute of Oncology Ljubljana Slovenia

Departments of Surgery and Otolaryngology Head and Neck Surgery Edinburgh University Edinburgh UK

Instituto Universitario de Oncología del Principado de Asturias Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC ISCIII University of Oviedo Oviedo Spain

University of Udine School of Medicine Udine Italy

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