The development of biologically active molecules based on molecular recognition is an attractive and challenging task in medicinal chemistry and the molecules that can activate/deactivate certain receptors are of great medical interest. In this contribution, selected pyrimidine/piperidine derivatives were synthesized and tested for the ability to activate/deactivate Aryl hydrocarbon receptor (AhR) and Glucocorticoid receptor (GR). Tested compounds are shown to activate the receptors but to much lesser extent than positive controls, dioxin and dexamethasone for Ahr and GR, respectively. However, some of them antagonized the positive controls action. Although further in vivo studies are needed to fully characterize the bioactivities of these compounds, the reported in vitro evidences demonstrate that they might be used as the modulators of AhR and GR activities.

Bioinformatics and High Performance Computing Research Group 30107 Murcia Spain

Bioinformatics Centre Biotech Park Sector G Jankipuram Lucknow 226021 Uttar Pradesh India

Department of Cell Biology and Genetics Palacky University Olomouc Czech Republic

Interdisciplinary Research Center in Biomedical Materials COMSATS Institute of Information Technology Lahore 54000 Pakistan

Interdisciplinary Research Center in Biomedical Materials COMSATS Institute of Information Technology Lahore 54000 Pakistan; Department of Chemistry The Islamia University of Bahawalpur Bahawalpur 63100 Pakistan

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