The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.

*Department of Dermatology Venereology and Allergology University Medical Center Göttingen Göttingen Germany; †Dermatohistology and Oral Pathology Laboratory Munich Germany; ‡Department of Pathology Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic; §Bioptical Laboratory Pilsen Czech Republic; ¶Department of Pathology University of Texas MD Anderson Cancer Center Houston TX; ‖Department of Pathology University Medical Center Göttingen Göttingen Germany; **Dermatopathology Laboratory Zurich Switzerland; and ††Department of Dermatology University Hospital Zurich Switzerland

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