Arbitrariness in the genetic code is one of the main reasons for a linguistic approach to molecular biology: the genetic code is usually understood as an arbitrary relation between amino acids and nucleobases. However, from a semiotic point of view, arbitrariness should not be the only condition for definition of a code, consequently it is not completely correct to talk about "code" in this case. Yet we suppose that there exist a code in the process of protein synthesis, but on a higher level than the nucleic bases chains. Semiotically, a code should be always associated with a function and we propose to define the genetic code not only relationally (in basis of relation between nucleobases and amino acids) but also in terms of function (function of a protein as meaning of the code). Even if the functional definition of meaning in the genetic code has been discussed in the field of biosemiotics, its further implications have not been considered. In fact, if the function of a protein represents the meaning of the genetic code (the sign's object), then it is crucial to reconsider the notion of its expression (the sign) as well. In our contribution, we will show that the actual model of the genetic code is not the only possible and we will propose a more appropriate model from a semiotic point of view.

Department of General Linguistics Palacký University Křížkovského 14 771 47 Olomouc Czech Republic

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Nature. 2002 Nov 14;420(6912):211-7 PubMed

Br J Philos Sci. 2016 Sep;67(3):707-730 PubMed

Adv Exp Med Biol. 2012;724:76-90 PubMed

Biosemiotics. 2016 Apr;9(1):103-129 PubMed

J Mol Evol. 2001 Oct-Nov;53(4-5):394-401 PubMed

Theory Biosci. 2007 Oct;126(2-3):65-113 PubMed

FEBS J. 2005 Jul;272(14):3673-83 PubMed

Ann N Y Acad Sci. 1999 May 18;870:411-7 PubMed

J Mol Biol. 1968 Dec;38(3):367-79 PubMed

Entropy (Basel). 2010 Apr 27;12(5):1050-1070 PubMed

J Theor Biol. 1985 Oct 7;116(3):399-426 PubMed

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9265-70 PubMed