Degradation of phospholipids under different types of irradiation and varying oxygen saturation
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
28500389
DOI
10.1007/s00411-017-0693-6
PII: 10.1007/s00411-017-0693-6
Knihovny.cz E-zdroje
- Klíčová slova
- DOPC, Electrons, Gamma rays, Lipid peroxidation, Oxygen saturation, Protons,
- MeSH
- elektrony MeSH
- fosfolipidy metabolismus MeSH
- kyslík metabolismus MeSH
- lipidové peroxidy metabolismus MeSH
- protony MeSH
- vztah dávky záření a odpovědi MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fosfolipidy MeSH
- kyslík MeSH
- lipidové peroxidy MeSH
- protony MeSH
The effects of different types of radiation on the formation of peroxide forms of 2-dioleoyl-sn-glycero-3-phosphocholine were studied under various conditions. For the irradiation, an aqueous solution of small unilamellar vesicles was prepared. Variations in parameters such as the dose rate and molecular oxygen saturation levels were evaluated. Our study suggests that the mechanism of the peroxides formation process remains unchanged under irradiation by accelerated electrons, gamma and accelerated protons. The values of radiation chemical yields of the peroxidic form depend on the type of radiation, dose rate, and the saturation of molecular oxygen. The level of oxygen saturation strongly affects the values of radiation chemical yields as well, as the dissolved oxygen is an important agent participating in peroxidation and it is a source of free radicals during the radiolysis. The values of radiation chemical yields strongly suggest that the mechanism of radiation-induced peroxidation of phosphatidylcholines does not proceed via chain reaction.
FNSPE Czech Technical University Prague Břehová 7 115 19 Prague Czech Republic
Institute of Physics of the CAS Na Slovance 1999 2 182 21 Prague Czech Republic
Institute of Plasma Physics of the CAS Za Slovankou 3 182 00 Prague Czech Republic
Nuclear Physics Institute of the CAS Husinec Řež 130 250 68 Řež Czech Republic
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