Aripiprazole-induced adverse metabolic alterations in polyI:C neurodevelopmental model of schizophrenia in rats
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
PubMed
28595931
DOI
10.1016/j.neuropharm.2017.06.003
PII: S0028-3908(17)30273-3
Knihovny.cz E-zdroje
- Klíčová slova
- Adipokine, Aripiprazole, Leptin, Lipid profile, PolyI:C, Schizophrenia, Wistar rats,
- MeSH
- antipsychotika škodlivé účinky farmakologie MeSH
- aplikace orální MeSH
- aripiprazol škodlivé účinky farmakologie MeSH
- cytokiny krev MeSH
- ghrelin krev MeSH
- glukagonu podobný peptid 1 krev MeSH
- leptin krev MeSH
- metabolický syndrom krev chemicky indukované MeSH
- modely nemocí na zvířatech MeSH
- náhodné rozdělení MeSH
- poly I-C MeSH
- potkani Wistar MeSH
- schizofrenie krev farmakoterapie MeSH
- tělesná hmotnost účinky léků MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antipsychotika MeSH
- aripiprazol MeSH
- cytokiny MeSH
- ghrelin MeSH
- glukagonu podobný peptid 1 MeSH
- leptin MeSH
- poly I-C MeSH
Schizophrenia appears to be linked to higher incidence of metabolic syndrome even in the absence of antipsychotic treatment. Atypical antipsychotics substantially differ in their propensity to induce metabolic alterations. Aripiprazole is considered to represent an antipsychotic drug with low risk of metabolic syndrome development. The aim of this study was to evaluate metabolic phenotype of neurodevelopmental polyI:C rat model and assess metabolic effects of chronic aripiprazole treatment with regard to complex neuroendocrine regulations of energy homeostasis. Polyinosinic:polycytidylic acid (polyI:C) was administered subcutaneously at a dose of 8 mg/kg in 10 ml on gestational day 15 to female Wistar rats. For this study 20 polyI:C and 20 control adult male offspring were used, randomly divided into 2 groups per 10 animals for chronic aripiprazole treatment and vehicle. Aripiprazole (5 mg/kg, dissolved tablets, ABILIFY®) was administered once daily via oral gavage for a month. Altered lipid profile in polyI:C model was observed and a trend towards different dynamics of weight gain in polyI:C rats was noted in the absence of significant antipsychotic treatment effect. PolyI:C model was not associated with changes in other parameters i.e. adipokines, gastrointestinal hormones and cytokines levels. Aripiprazole did not influence body weight but it induced alterations in neurohumoral regulations. Leptin and GLP-1 serum levels were significantly reduced, while ghrelin level was elevated. Furthermore aripiprazole decreased serum levels of pro-inflammatory cytokines. Our data indicate dysregulation of adipokines and gastrointestinal hormones present after chronic treatment with aripiprazole which is considered metabolically neutral in the polyI:C model of schizophrenia.
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Psychiatry University Hospital and Masaryk University Brno Czech Republic
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