Relative amount of telomeric sequences in terminal villi does not differ between normal term placentas and placentas from patients with well-controlled type 1 diabetes mellitus
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
28623966
DOI
10.1016/j.placenta.2017.04.016
PII: S0143-4004(17)30238-2
Knihovny.cz E-resources
- Keywords
- Chorionic villi, Diabetes, Pregnancy, Telomere sequence, Telomere/single copy gene ratio, qPCR,
- MeSH
- Diabetes Mellitus, Type 1 physiopathology MeSH
- Adult MeSH
- Telomere Homeostasis * MeSH
- Laser Capture Microdissection MeSH
- Humans MeSH
- Young Adult MeSH
- Placenta physiology MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
We applied qPCR to compare relative telomere length in terminal villi microdissected from term control placentas and placentas of patients suffering from type 1 diabetes. Significant differences were not found in the relative T/S ratios between placental groups or between the diabetic placentas affected and those not affected with chorangiosis. We hypothesize that there is no relationship between decreased placental proliferative ability in maternal diabetes type 1 and telomere shortening.
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