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Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group

Balduzzi, A
Author Balduzzi, A Clinica Pediatrica, Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy
Dalle, J-H
Author Dalle, J-H Hemato-Immunology Department, Robert-Debre Hospital, APHP and Paris-Diderot University, Paris, France
Jahnukainen, K
Author Jahnukainen, K Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
von Wolff, M
Author von Wolff, M Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynecology, Inselspital Bern, University Hospital, Bern, Switzerland
Lucchini, G
Author Lucchini, G Bone Marrow Transplant Department, Great Ormond Street Hospital, London, UK
Ifversen, M
Author Ifversen, M Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Macklon, K T
Author Macklon, K T The Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark
Poirot, C
Author Poirot, C Adolescent and Young Adult Hematology Unit, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie, Paris, France
Diesch, T
Author Diesch, T Department of Pediatric Hematology/Oncology, University Children's Hospital of Basel, Basel, Switzerland
Jarisch, A
Author Jarisch, A Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany
Bresters, D
Author Bresters, D Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
Yaniv, I
Author Yaniv, I Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Gibson, B
Author Gibson, B Department of Paediatric Haematology, Royal Hospital for Children, Scotland, UK
Willasch, A M
Author Willasch, A M Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany
Fadini, R
Author Fadini, R Centro di Medicina della Riproduzione Biogenesi, Istituti Clinici Zucchi, Monza, Italy
Ferrari, L
Author Ferrari, L Department of Gynecology and Obstetrics, Ospedale San Gerardo di Monza, Monza, Italy
Lawitschka, A
Author Lawitschka, A St Anna Children's Hospital, UKKJ, MUW, Vienna, Austria
Ahler, A
Author Ahler, A Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, University Hospital, Basel, Switzerland
Sänger, N
Author Sänger, N Division of Reproductive Medicine, Endocrinology and Infertility, Department of Obstetrics and Gynecology, University Hospital, JW Goethe University, Frankfurt, Germany
Corbacioglu, S
Author Corbacioglu, S Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital, University of Regensburg, Regensburg, Germany
Ansari, M
Author Ansari, M Department of Pediatrics, Hémato-Oncologie Pédiatrique, CANSEARCH Research Laboratory, Université de Médecine de Genève, Geneva, Switzerland
Moffat, R
Author Moffat, R Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, University Hospital, Basel, Switzerland
Dalissier, A
Author Dalissier, A EBMT Paris Office, Hospital Saint Antoine, Paris, France
Beohou, E
Author Beohou, E EBMT Paris Office, Hospital Saint Antoine, Paris, France
Sedlacek, P
Author Sedlacek, P Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic
Lankester, A
Author Lankester, A Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands
De Heredia Rubio, C D
Author De Heredia Rubio, C D Pediatric Oncology and Hematology Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain
Vettenranta, K
Author Vettenranta, K Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Wachowiak, J
Author Wachowiak, J Department of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, Poland
Yesilipek, A
Author Yesilipek, A Bahcesehir University School of Medicine, Department of Pediatrics, Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey
Trigoso, E
Author Trigoso, E Paediatric Oncology Unit, Paediatric Transplant Unit, Polytechnic and University Hospital 'LA FE', Valencia, Spain
Klingebiel, T
Author Klingebiel, T Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany
Peters, C
Author Peters, C ORCID St Anna Children's Hospital, UKKJ, MUW, Vienna, Austria
Bader, P
Author Bader, P Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany

Bone marrow transplantation. 2017 Oct ; 52 (10) : 1406-1415. [epub] 20170724

Bone Marrow Transplant
ISSN 1476-5365 | 0268-3369
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Multicenter Study

Persistent link https://www.medvik.cz/link/pmid28737775

PubMed 28737775
DOI 10.1038/bmt.2017.147
PII: bmt2017147
Knihovny.cz E-resources

MeSH
Allografts MeSH
Child MeSH
Consensus * MeSH
Cryopreservation methods MeSH
Humans MeSH
Adolescent MeSH
Ovary * MeSH
Antineoplastic Agents adverse effects therapeutic use MeSH
Practice Guidelines as Topic MeSH
Testis * MeSH
Hematopoietic Stem Cell Transplantation * MeSH
Fertility Preservation methods MeSH
Check Tag
Child MeSH
Humans MeSH
Adolescent MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Names of Substances
Antineoplastic Agents MeSH

Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender- and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy. Semen collection should be routinely offered to all postpubertal boys at the diagnosis of any disease requiring therapy that could potentially impair fertility. Testicular tissue collection might be offered to postpubertal boys; nevertheless, its use has been unsuccessful to date. Oocyte collection after hormonal hyperstimulation should be offered to postpubertal girls facing gonadotoxic therapies that could be delayed for the 2 weeks required for the procedure. Ovarian tissue collection could be offered to pre-/post-pubertal girls. Pregnancies have been reported after postpubertal ovarian tissue reimplantation; however, to date, no pregnancy has been reported after the reimplantation of prepubertal ovarian tissue or in vitro maturation of pre-/post-pubertal ovarian tissue. Possible future advances in reproductive medicine could change this scenario. Health authorities should prioritize fertility preservation projects in pediatric transplantation to improve patient care and quality of life.

Adolescent and Young Adult Hematology Unit Saint Louis Hospital Assistance Publique Hôpitaux de Paris University Pierre et Marie Curie Paris France

Bahcesehir University School of Medicine Department of Pediatrics Pediatric Stem Cell Transplantation Unit Istanbul Turkey

Bone Marrow Transplant Department Great Ormond Street Hospital London UK

Centro di Medicina della Riproduzione Biogenesi Istituti Clinici Zucchi Monza Italy

Clinica Pediatrica Università degli Studi di Milano Bicocca Fondazione Monza e Brianza per il Bambino e la sua Mamma Ospedale San Gerardo Monza Italy

Department of Gynecology and Obstetrics Ospedale San Gerardo di Monza Monza Italy

Department of Paediatric Haematology Royal Hospital for Children Scotland UK

Department of Pediatric and Adolescent Medicine Rigshospitalet Copenhagen University Hospital Copenhagen Denmark

Department of Pediatric Hematology and Oncology University Hospital Motol Prague Czech Republic

Department of Pediatric Hematology Oncology and Stem Cell Transplantation University Hospital University of Regensburg Regensburg Germany

Department of Pediatric Hematology Oncology University Children's Hospital of Basel Basel Switzerland

Department of Pediatric Oncology Hematology and Transplantology University of Medical Sciences Poznan Poland