Nowadays, allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment procedure and often the only cure for many patients with malignant and non-malignant diseases. Decrease in short-term complications has substantially contributed to increased survival. Therefore long-term sequelae are reaching the focus of patient care. One of the most important risks of stem cell transplant survivors is infertility. As well as in the field of allo-HSCT also the field of reproductive medicine has achieved substantial advances to offer potential options for fertility preservation in both boys and girls. Access to these procedures as well as their financing differs significantly throughout Europe. As all European children and adolescents should have the same possibility, the Paediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation organised an expert meeting in September 2015. This manuscript describes the recommendations for the diagnosis and pre-emptive procedures that should be offered to all children and adolescents in Europe who have to undergo an allo-HSCT.

Adolescents and Young Adults Hematology Unit Saint Louis Hospital Assistance Publique Hôpitaux de Paris University Pierre et Marie Curie Paris France

CANSEARCH Research Laboratory Geneva University Geneva Switzerland

Clinic for Gynaecologic Endocrinology and Reproductive Medicine University Hospital Basel Switzerland

Clinica Pediatrica Università degli Studi di Milano Bicocca Fondazione Monza e Brianza per il Bambino e la sua Mamma Ospedale San Gerardo di Monza Monza Italy

Department of Bone Marrow Transplant Great Ormond Street Hospital London UK

Department of Hemato immunology Robert Debre Hospital APHP Paris Diderot University Paris France

Department of Paediatric Haematology Royal Hospital for Children Glasgow UK

Department of Pediatric and Adolescent Medicine Rigshospitalet Copenhagen Denmark

Department of Pediatric Hematology and Oncology University Hospital Motol Prague Czech Republic

Department of Pediatric Hematology Oncology and Stem Cell Transplantation University Hospital University of Regensburg Regensburg Germany

Department of Pediatric Oncology and Hematology Hospital Universitario Vall d'Hebron Barcelona Spain

Department of Pediatric Oncology Hematology and Transplantology University of Medical Sciences Poznan Poland

Department of Pediatrics Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation Unit Istanbul Turkey

Department of Pediatrics Onco Hematology Unit Geneva University Hospitals Geneva Switzerland

Department of Women's and Children's Health Karolinska Institute University Hospital Stockholm Sweden

Division for Reproductive Endocrinology and Infertility Department for Gynecology and Obstetrics University Hospital Frankfurt Germany

Division for Stem Cell Transplantation and Immunology Department for Children and Adolescents University Hospital Frankfurt Goethe University Frankfurt am Main Germany

Division of Hematology Oncology and Stem Cell Transplantation Children's Hospital Helsinki University Hospital Helsinki Finland

Division of Paediatric Oncology Haematology University Children's Hospital of Basel Basel Switzerland

Division of Reproductive Medicine and Endocrinology Department of Obstetrics and Gynaecology Inselspital Bern University Hospital Bern Switzerland

EBMT Paris Office Hospital Saint Antoine Paris France

Hospital for Children and Adolescents University of Helsinki Helsinki Finland

Paediatric Oncology Unit Paediatric Transplant Unit Polytechnic and University Hospital 'LA FE' Valencia Spain

Pediatric Hematology Oncology Schneider Children's Medical Center of Israel Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

St Anna Children's Hospital Universitätsklinik für Kinder und Jugendheilkunde Medizinische Universität Wien Vienna Austria

The Fertility Clinic Section 4071 University Hospital of Copenhagen Rigshospitalet Copenhagen Denmark

Willem Alexander Children's Hospital Leiden University Medical Center Leiden The Netherlands

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